Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-971-6 | CAS number: 10476-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Read across from Sr(NO3)2 to SrCl2 is envisaged and fully justified since possible effects occurred during testing could be regarded as strontium ion related effects. Furthermore, both substances (SrCl2 and Sr(NO3)2) are "very soluble" (above 10 g/L at 20°C) in water.
Tests on the mutagenic potential of strontium compounds in bacteria are considered dispensable for principal considerations, since inorganic metal compounds are frequently negative in this assay due to limited capacity for uptake of metal ions (Guidance on information requirements and chemical safety assessment, Chapter R.7a, p. 387; HERAG facts sheet mutagenicity, Chapter 2.1).
It is concluded that strontium chloride did not induce micronuclei in cultured human peripheral blood lymphocytes following treatments in the absence and presence of an Aroclor induced rat liver metabolic activation system (S-9 mix). Concentrations were tested and analysed up to 2116 µg/mL.
Furthermore, it is concluded that strontium nitrate did not induce mutation at the tk locus of L5178Y mouse lymphoma cells when tested under the conditions employed in this study .
These conditions included treatments up to precipitating concentrations in two independent experiments, in the absence and presence of a rat liver metabolic activation system (S-9 mix).
Further testing of in vivo genetic toxicity tests is not considered necessary.
Justification for selection of genetic toxicity endpoint
Three in vitro key studies are available addressing bacterial reverse mutation, in vitro gene mutation and chromosome aberration for strontium chloride and strontium nitrate respectively. Read-across between strontium chloride and strontium nitrate is performed and fully justified (see discussion below). Due to the outcome of these tests strontium chloride could be regarded to have no mutagenic / genotoxic potential.
Short description of key information:
Strontium substances have been tested in bacterial reverse mutation assays, in vitro gene mutation and chromosome aberration test.
- in-vitro gene mutation in bacteria (OECD 471): negative
- in-vitro gene mutation in mammalian cells (OECD 476): negative (no data is available for SrCl2, thus read-across from Sr(NO3)2 was performed)
- in-vitro chromosome aberration (OECD 473): negative (no data is available for SrCl2, thus read-across from Sr(NO3)2 was performed)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
All available reliable studies showed no genetic toxicity for strontium chloride or strontium nitrate. Read-across between strontium chloride and strontium nitrate was performed and is fully justified. Thus, strontium chloride could be regarded to have no mutagenicity / genotoxicity effects, tested in vitro. Hence, no classification and labelling is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.