Registration Dossier
Registration Dossier
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EC number: 230-237-7 | CAS number: 6976-37-0
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- Regulation (EC) No 440/2008, Method A.1
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- OECD Guideline No. 102 for the testing of chemicals, 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- capillary method
- Key result
- Melting / freezing pt.:
- 104 °C
- Atm. press.:
- ca. 101 325 Pa
- Decomposition:
- no
- Conclusions:
- The mean melting temperature of the test item is 104.0 °C, with a standard deviation of 0.42.
- Executive summary:
The melting point of the test item was determined according to OECD test guideline 102 and Regulation (EC) No 440/2008, Method A.1. The solid test substance was filled into 3 capillary melting point tubes, which were placed in a melting point apparatus. The samples were heated from 90 to 120 °C at a rate of 1 K/min. The mean melting temperature of the test item was determined to be 104.0 °C, with a standard deviation of 0.42.
In addition, the melting point was calculated using the software MPBWIN (Version 1.43) as 156.67 °C.
Reference
At the start of the test at 90 °C the test substance was a white powder and started melting at about 103 °C. The results of 3 repeated determinations of the melting temperature of the test substance were: 104.1, 103.5 and 104.3 °C. The mean melting temperature of the test item is 104.0 °C, with a standard deviation of 0.42. Testing the control substances caffeine (mean melting temperature of 236.2 °C; target temperature: 236.1 °C) and benzoic acid (melting point temperature of 122.3 °C; target temperature: 122.3 °C) confirmed the reliability of the apparatus.
Description of key information
The mean melting temperature of the test item is 104.0 °C, with a standard deviation of 0.42 (referenc 4.2-1).
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 104 °C
Additional information
The melting point of the test item was determined according to OECD test guideline 102 and Regulation (EC) No 440/2008, Method A.1. The solid test substance was filled into 3 capillary melting point tubes, which were placed in a melting point apparatus. The samples were heated from 90 to 120 °C at a rate of 1 K/min. The mean melting temperature of the test item was determined to be 104.0 °C, with a standard deviation of 0.42.
In addition, the melting point was calculated using the software MPBWIN (Version 1.43) as 156.67 °C.
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