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Diss Factsheets
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EC number: 226-242-9 | CAS number: 5333-42-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No experimental data on toxicokinetics, metabolism and distribution is available for 2 -octyldodecan-1-ol or any other structural analogue of the Guerbet alcohol category. Based on the physical-chemical properties of Guerbet alcohols and the available toxicity data the following assumptions can be made.
2 -Octyldodecan-1-ol has a very low water solubility below 1 mg/l. Therefore the dissolution of the substance is regarded as the rate limiting step for the absorption process from gastrointestinal tract. Amounts of the substance which were absorbed are distributed within the organism by systemic circulation. Due to its lipophilic properties (log Pow > 6) absorbed 2 -octyldodecan-1-ol can bind to plasma proteins and a theoretical bioaccumulation in fat tissue cannot totally be excluded, nevertheless the substance is expected to be extensively metabolised.
As first step of the biotransformation of resorbed 2 -octyldodecan-1-ol mainly the oxidation of the alcohol to the corresponding carboxylic acid by phase I enzymes is expected. The carboxylic acid is then expected to be glucoronised by the phase II enzymes UDP-glucuronosyltransferases to the ester glucuronides and excreted. Only minor parts of 2 -octyldodecan-1-ol are expected to be metabolized and excreted as alcohol glucuronides.
This described metabolism is highly efficient and 2 -octyldodecan-1-ol is therefore not expected to have a tissue retention or bioaccumulation potential. This is supported by the available oral sub-chronic toxicity study of 2-octyldodecan-1-ol which shows no substance-dependent toxic effects at doses of 1 ml/kg bw/d.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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