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EC number: 222-426-8 | CAS number: 3468-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-02-02 to 2018-03-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products:
Preliminary Test (Tier 1):
pH 4 at 50 °C: sampling at 0, 0.5, 1, 1.5, 2, 3, 3.5 and 4 h;
pH 7 at 50 °C: sampling at 0, 2, 3, 4, 4.5, 5, 5.5, 6 h;
pH 9 at 50 °C: sampling at 0, 1, 2, 2.5, 3, 3.5, 4, 4.5 h.
Main Test (Tier 2):
pH 4 at 20 °C: sampling at 0, 3, 24, 28, 48, 55, 72, 98 h;
pH 7 at 20 °C: sampling at 0, 3, 24, 48, 98, 146, 170, 191 h;
pH 9 at 20 °C: sampling at 0, 3, 24, 28, 48, 72, 98, 144 h;
pH 4 at 35 °C: sampling at 0, 1, 2, 3, 4, 5, 6, 7, 8 h;
pH 7 at 35 °C: sampling at 0, 3, 7, 24, 27, 29, 31, 47.5 h;
pH 9 at 35 °C: sampling at 0, 3, 7, 24, 28, 48, 55 h;
pH 4 at 50 °C: sampling at 0, 0.5, 1, 1.5, 2, 3, 3.5, 4 h;
pH 7 at 50 °C: sampling at 0, 2, 3, 4, 4.5, 5, 5.5, 6 h;
pH 9 at 50 °C: sampling at 0, 1, 2, 2.5, 3, 3.5, 4, 4.5 h;
- Sampling method: At each sampling time 2 mL diluent were added (dilution factor 2). The samples were homogenised by shaking after recrimbing. Two vials were prepared for each pH and each sampling date.
- Sampling intervals/times for pH measurements: same as sampling intervals for content determine
- Sample storage conditions before analysis: directly used for analysis - Buffers:
- - Tested pH values: 4, 7, 9
- Type and final molarity of buffer: The citrate buffer (pH 4), the phosphate buffer (pH 7), and the borate buffer (pH 9) were prepared in a concentration of 0.05 M on the basis of the undissociated acids.
- Composition of buffer:
Citrate buffer pH 4 (0.05 M): Per 1 L ultra-pure water about 10.505 g citric acid monohydrate was weighed and about 60 mL of sodium hydroxide solution (1 M) was added to reach pH 4.
Phosphate buffer pH 7 (0.05 M): Per 1 L ultra-pure water about 6.805 g potassium dihydrogenphosphate was weighed and about 30 mL of sodium hydroxide solution (1 M) was added to reach pH 7.
Borate buffer pH 9 (0.05 M): Per 1 L ultra-pure water about 3.902 g boric acid and about 3.728 g potassium chloride were weighed and 21 mL of sodium hydroxide solution (1 M) were added to reach pH 9. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks: 6 mL crimp vials
- Sterilisation method: Sterile buffer solutions used, sterilised by autoclaving
- Lighting: dark
- Measures taken to avoid photolytic effects: shaking in the dark
- Measures to exclude oxygen: degassing the buffers with argon for at least five minutes and purging the vessels with argon before preparing the test solution
- If no traps were used, is the test system closed/open: closed, with teflon sealed crimp caps
TEST PROCEDURE
- Test item preparation: At pH 4 and 9 about 100 mg and at pH 7 about 15 mg were given into a 100 mL volumetric flask. Afterwards the flask was brought to volume with the corresponding buffer solutions.
- Test concentration: 1000 mg/L at pH 4 and pH 9, 150 mg/L at pH 7
- Preliminary Test (Tier 1): performed at 50 ± 0.5 °C at three pH values 4, 7 and 9,
- Main Test (Tier 2): performed at pH 4, 7 and 9 at 20 °C, 35°C and 50°C - Duration:
- 4 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 978.2 mg/L
- Remarks:
- Preliminary Test (Tier 1)
- Duration:
- 6 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 194.4 mg/L
- Remarks:
- Preliminary Test (Tier 1)
- Duration:
- 4.5 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 920.3 mg/L
- Remarks:
- Preliminary Test (Tier 1)
- Duration:
- 98 h
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 951.7 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 191 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 102.2 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 144 h
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- 1 018.7 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 8 h
- pH:
- 4
- Temp.:
- 35 °C
- Initial conc. measured:
- 1 014.8 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 47.5 h
- pH:
- 7
- Temp.:
- 35 °C
- Initial conc. measured:
- 102.2 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 55 h
- pH:
- 9
- Temp.:
- 35 °C
- Initial conc. measured:
- 1 018.7 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 4 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 978.2 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 6 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 194.4 mg/L
- Remarks:
- Main Test (Tier 2)
- Duration:
- 4.5 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 920.3 mg/L
- Remarks:
- Main Test (Tier 2)
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- More than 10 % of the test item were hydrolysed within 4 hours (for pH 4), respectively 6 hours (for pH 7) and 4.5 hours (for pH 9) at 50 °C. The Tier 2 test was performed for each pH value.
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- -0.013 h-1
- DT50:
- 22 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- -0.003 h-1
- DT50:
- 94 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- -0.003 h-1
- DT50:
- 105 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 35 °C
- Hydrolysis rate constant:
- -0.057 h-1
- DT50:
- 5.1 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 35 °C
- Hydrolysis rate constant:
- -0.019 h-1
- DT50:
- 18 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 35 °C
- Hydrolysis rate constant:
- -0.016 h-1
- DT50:
- 18 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- -0.185 h-1
- DT50:
- 1.5 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- -0.059 h-1
- DT50:
- 5.4 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- -0.076 h-1
- DT50:
- 4.1 h
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- TEST CONDITIONS
- pH, temperature maintained throughout the study: Yes - Validity criteria fulfilled:
- yes
- Conclusions:
- The determined degradation half-life values are 22, 94, 105 h at 20°C for pH 4, 7, 9; 5.1, 18, 18 h at 35°C for pH 4, 7, 9; 1.5, 5.4, 4.1 h at 50°C for pH 4, 7, 9, respectively.
- Executive summary:
The abiotic degradation of test item as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008).
A preliminary test was performed at 50 ± 0.5 °C at three pH values 4, 7 and 9. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, less than 10 % of hydrolysis is observed after 120 hours or not. The hydrolysis of test item was more than 10 % at pH 4, 7 and 9 at 50 °C over a period of 2 hours.
The main test (Tier 2) was performed at pH 4, 7 and 9. The buffered solution of the test substance was tempered at 20 °C ± 0.5 °C, 35 °C ± 0.5 °C and 50 °C ± 0.5 °C. To test for first-order behaviour, each reaction solution was analysed in time intervals which provide at least six spaced data points normally between 10 % and 90 % hydrolysis of the substance.
The determined degradation half-life values are 22, 94, 105 h at 20°C for pH 4, 7, 9; 5.1, 18, 18 h at 35°C for pH 4, 7, 9; 1.5, 5.4, 4.1 h at 50°C for pH 4, 7, 9, respectively.
Reference
Main test Tier 2:
Time course of test item concentration at pH 4 at 20 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
956.0 |
951.7 |
100 |
0.00000 |
4.12 |
|
947.4 |
|
|
|
|
3 |
841.4 |
841.8 |
88 |
-0.05329 |
4.10 |
|
842.2 |
|
|
|
|
24 |
447.6 |
446.1 |
47 |
-0.32907 |
4.14 |
|
444.6 |
|
|
|
|
28 |
398.0 |
395.9 |
42 |
-0.38091 |
4.14 |
|
393.8 |
|
|
|
|
48 |
223.4 |
221.8 |
23 |
-0.63254 |
4.16 |
|
220.2 |
|
|
|
|
55 |
177.0 |
176.7 |
19 |
-0.73126 |
4.17 |
|
176.4 |
|
|
|
|
72 |
103.4 |
102.8 |
11 |
-0.96651 |
4.15 |
|
102.2 |
|
|
|
|
98 |
59.2 |
59.5 |
6 |
-1.20398 |
4.17 |
|
59.8 |
|
|
|
|
Time course of Test item concentration at pH 7 at 20 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
102.4 |
102.2 |
100 |
0.00000 |
7.10 |
|
102.0 |
|
|
|
|
3 |
100.0 |
100.2 |
98 |
-0.00858 |
7.05 |
|
100.4 |
|
|
|
|
24 |
87.6 |
87.7 |
86 |
-0.06645 |
7.04 |
|
87.8 |
|
|
|
|
48 |
75.2 |
75.0 |
73 |
-0.13439 |
7.05 |
|
74.8 |
|
|
|
|
98 |
61.4 |
61.3 |
60 |
-0.22199 |
7.05 |
|
61.2 |
|
|
|
|
146 |
35.0 |
35.1 |
34 |
-0.46414 |
7.05 |
|
35.2 |
|
|
|
|
170 |
26.6 |
26.5 |
26 |
-0.58621 |
7.06 |
|
26.4 |
|
|
|
|
191 |
21.8 |
21.8 |
21 |
-0.67099 |
7.05 |
|
21.8 |
|
|
|
|
Time course of Test item concentration at pH 9 at 20 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
1025.2 |
1018.7 |
100 |
0.00000 |
9.07 |
|
1012.2 |
|
|
|
|
3 |
1003.6 |
986.8 |
97 |
-0.01382 |
8.97 |
|
970.0 |
|
|
|
|
24 |
838.6 |
835.6 |
82 |
-0.08605 |
9.04 |
|
832.6 |
|
|
|
|
28 |
815.8 |
817.5 |
80 |
-0.0956 |
9.08 |
|
819.2 |
|
|
|
|
48 |
739.2 |
737.5 |
72 |
-0.1403 |
9.09 |
|
735.8 |
|
|
|
|
72 |
629.4 |
630.5 |
62 |
-0.2084 |
9.09 |
|
631.6 |
|
|
|
|
98 |
536.8 |
538.5 |
53 |
-0.2769 |
9.09 |
|
540.2 |
|
|
|
|
144 |
396.2 |
395.1 |
39 |
-0.4113 |
9.08 |
|
394.0 |
|
|
|
|
Time course of Test item concentration at pH 4 at 35 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
1017.0 |
1014.8 |
100 |
0.0000 |
4.10 |
|
1012.6 |
|
|
|
|
1 |
863.2 |
861.9 |
85 |
-0.07092 |
4.07 |
|
860.6 |
|
|
|
|
2 |
740.6 |
743.4 |
73 |
-0.13516 |
4.09 |
|
746.2 |
|
|
|
|
3 |
662.6 |
660.3 |
65 |
-0.18664 |
4.09 |
|
658.0 |
|
|
|
|
4 |
587.2 |
587.2 |
58 |
-0.23759 |
4.09 |
|
587.2 |
|
|
|
|
5 |
513.4 |
508.7 |
50 |
-0.29992 |
4.09 |
|
506.4 |
|
|
|
|
6 |
451.6 |
449 |
44 |
-0.35413 |
4.12 |
|
449.6 |
|
|
|
|
7 |
390.6 |
393.4 |
39 |
-0.41155 |
4.12 |
|
401.0 |
|
|
|
|
8 |
353.0 |
351.1 |
35 |
-0.46095 |
4.14 |
|
352.4 |
|
|
|
|
Time course of Test item concentration at pH 7 at 35 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
102.4 |
102.2 |
100 |
0.0000 |
7.10 |
|
102.0 |
|
|
|
|
3 |
95.4 |
95.4 |
93 |
-0.0299 |
7.05 |
|
95.4 |
|
|
|
|
7 |
87.0 |
86.7 |
85 |
-0.0714 |
7.07 |
|
86.4 |
|
|
|
|
24 |
41.8 |
41.7 |
41 |
-0.3893 |
7.03 |
|
41.6 |
|
|
|
|
27 |
35.6 |
35.9 |
35 |
-0.4544 |
7.05 |
|
36.2 |
|
|
|
|
29 |
33.0 |
32.8 |
32 |
-0.4936 |
7.04 |
|
32.6 |
|
|
|
|
31 |
30.0 |
29.9 |
29 |
-0.5338 |
7.03 |
|
29.8 |
|
|
|
|
47.5 |
13.2 |
13.2 |
13 |
-0.8889 |
7.04 |
|
13.2 |
|
|
|
|
Time course of Test item concentration at pH 9 at 35 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
1025.2 |
1018.7 |
100 |
0.00000 |
9.07 |
|
1012.2 |
|
|
|
|
3 |
904.8 |
906.0 |
89 |
-0.05092 |
9.02 |
|
907.2 |
|
|
|
|
7 |
777.8 |
773.2 |
76 |
-0.11975 |
9.03 |
|
768.6 |
|
|
|
|
24 |
409.0 |
409.8 |
40 |
-0.39547 |
9.03 |
|
410.6 |
|
|
|
|
28 |
350.6 |
349.6 |
34 |
-0.4645 |
9.05 |
|
348.6 |
|
|
|
|
48 |
160.8 |
161.9 |
16 |
-0.7988 |
9.02 |
|
163.0 |
|
|
|
|
55 |
128.2 |
128.2 |
13 |
-0.9002 |
9.03 |
|
128.2 |
|
|
|
|
Time course of Test item concentration at pH 4 at 50 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
984.6 |
978.2 |
100 |
0.0000 |
4.14 |
|
971.8 |
|
|
|
|
0.5 |
743.6 |
746.6 |
76 |
-0.1173 |
4.10 |
|
749.6 |
|
|
|
|
1 |
595.8 |
593.6 |
61 |
-0.2169 |
4.16 |
|
591.4 |
|
|
|
|
1.5 |
476.2 |
477.6 |
49 |
-0.3114 |
4.13 |
|
479.0 |
|
|
|
|
2 |
377.4 |
376.5 |
38 |
-0.4147 |
4.14 |
|
375.6 |
|
|
|
|
3 |
261.4 |
261.5 |
27 |
-0.5730 |
4.18 |
|
261.6 |
|
|
|
|
3.5 |
211.2 |
211.9 |
22 |
-0.6643 |
4.16 |
|
212.6 |
|
|
|
|
4 |
172.2 |
172.3 |
18 |
-0.7541 |
4.15 |
|
172.4 |
|
|
|
|
Time course of Test item concentration at pH 7 at 50 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
194.0 |
194.4 |
100 |
0.0000 |
7.13 |
|
194.8 |
|
|
|
|
2 |
157.8 |
157.7 |
81 |
-0.0909 |
7.13 |
|
157.6 |
|
|
|
|
3 |
136.4 |
136.4 |
70 |
-0.1539 |
7.13 |
|
136.4 |
|
|
|
|
4 |
118.2 |
118.2 |
61 |
-0.2161 |
7.14 |
|
118.2 |
|
|
|
|
4.5 |
109.4 |
109.4 |
56 |
-0.2497 |
7.14 |
|
109.4 |
|
|
|
|
5 |
102.2 |
102.2 |
53 |
-0.2792 |
7.13 |
|
102.2 |
|
|
|
|
5.5 |
94.0 |
94.1 |
48 |
-0.3151 |
7.13 |
|
94.2 |
|
|
|
|
6 |
88.2 |
88.3 |
45 |
-0.3427 |
7.14 |
|
88.4 |
|
|
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Time course of Test item concentration at pH 9 at 50 °C:
Sampling time [h] |
Concentration in 2 independent samples [mg/L] |
Mean Concentration from 2 independent samples [mg/L] |
Concentration in % of initial concentration [%] |
log[c(t)/c(0)] |
pH |
0 |
920.2 |
920.3 |
100 |
0.0000 |
9.07 |
|
920.4 |
|
|
|
|
1 |
800.2 |
799.3 |
87 |
-0.0612 |
8.97 |
|
798.4 |
|
|
|
|
2 |
672.4 |
669.4 |
73 |
-0.1382 |
8.94 |
|
666.4 |
|
|
|
|
2.5 |
610.4 |
610.0 |
66 |
-0.1786 |
8.95 |
|
609.6 |
|
|
|
|
3 |
560.4 |
556.3 |
60 |
-0.2186 |
8.98 |
|
552.2 |
|
|
|
|
3.5 |
515.4 |
515.3 |
56 |
-0.2519 |
8.95 |
|
515.2 |
|
|
|
|
4 |
463.4 |
462.6 |
50 |
-0.2987 |
8.92 |
|
461.8 |
|
|
|
|
4.5 |
416.4 |
419.0 |
46 |
-0.3417 |
8.97 |
|
421.6 |
|
|
|
Description of key information
For this endpoint one test is available, in which theabiotic degradation of test item as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008).
The main test (Tier 2) was performed at pH 4, 7 and 9. The buffered solution of the test substance was tempered at 20 °C ± 0.5 °C, 35 °C ± 0.5 °C and 50 °C ± 0.5 °C. The determined degradation half-life values are 22, 94, 105 h at 20°C for pH 4, 7, 9; 5.1, 18, 18 h at 35°C for pH 4, 7, 9; 1.5, 5.4, 4.1 h at 50°C for pH 4, 7, 9, respectively.
The reported key value is the half-life at 20°C and at pH 7.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 94 h
- at the temperature of:
- 20 °C
Additional information
For this endpoint one test is available, in which theabiotic degradation of test item as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008).
A preliminary test was performed at 50 ± 0.5 °C at three pH values 4, 7 and 9. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, less than 10 % of hydrolysis is observed after 120 hours or not. The hydrolysis of test item was more than 10 % at pH 4, 7 and 9 at 50 °C over a period of 2 hours.
The main test (Tier 2) was performed at pH 4, 7 and 9. The buffered solution of the test substance was tempered at 20 °C ± 0.5 °C, 35 °C ± 0.5 °C and 50 °C ± 0.5 °C. To test for first-order behaviour, each reaction solution was analysed in time intervals which provide at least six spaced data points normally between 10 % and 90 % hydrolysis of the substance.
The determined degradation half-life values are 22, 94, 105 h at 20°C for pH 4, 7, 9; 5.1, 18, 18 h at 35°C for pH 4, 7, 9; 1.5, 5.4, 4.1 h at 50°C for pH 4, 7, 9, respectively.
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