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EC number: 221-882-5 | CAS number: 3268-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38409-51: Deutsche Einheitsverfahren zur Wasser-, Abwasser- und Schlammuntersuchung; Summarische Wirkungs- und Stoffkenngrößen (Gruppe H); Bestimmung des Biochemischen Sauerstoffbedarfs in n Tagen nach dem Verdünnungsprinzip (Verdünnungs-BSB) (H 51)
- Version / remarks:
- 1987
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38409-41: Deutsche Einheitsverfahren zur Wasser-, Abwasser- und Schlammuntersuchung; Summarische Wirkungs- und Stoffkenngrößen (Gruppe H); Bestimmung des Chemischen Sauerstoffbedarfs (CSB) im Bereich über 15 mg/L (H 41)
- Version / remarks:
- 1980
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Duration of test (contact time):
- 5 d
- Initial conc.:
- 1 g/L
- Based on:
- test mat.
- Initial conc.:
- 2 g/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- BOD5 :
TEST CONDITIONS
- Test temperature: 20 °C
- Continuous darkness: yes
TEST SYSTEM
0.1% solution of the test substance: 615 mg/L
0.2% solution of the test substance: 1170 mg/L
average: 600 mg BOD5/g of the test substance
COD :
Oxidation of the ingredients with potassium dichromate with the addition of silver sulphate as catalyst in a strongly sulphuric acid solution.
TEST CONDITIONS
- reaktion temperature: 20 °C
- reaction time: 2 h
COD
0.1% solution of the test substance: 1500 mg/L COD
0.2% solution of the test substance: 2950 mg/L COD
average: 1500 mg COD / g of the test substance - Reference substance:
- not required
- Parameter:
- BOD5
- Value:
- 600 mg O2/g test mat.
- Parameter:
- COD
- Value:
- 1 500 mg O2/g test mat.
- Parameter:
- BOD5*100/COD
- Value:
- 40
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The ready biodegradability of 3-(Methylthio)propionaldehyde was investigated in a study conducted to guideline DIN 38409-51 for BOD5 and DIN38409-41 for COD respectively. The average BOD5 after 5 days was 600 mg per g of the test substance. The average COD after 2 h of reaction was 1500 mg per g of the test substance. In case the BOD5/COD ratio is 0.5 or higher a substance can be regarded as readily biodegradable. Since this is not the case (0.4) the substance is regarded as not readily biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1992-10-29 to 1992-11-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- ISO DIS 9439 (Ultimate Aerobic Biodegradability - Method by Analysis of Released Carbon Dioxide)
- Version / remarks:
- December 1990
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Principles of method if other than guideline:
- Method similar to OECD 301B (DOC measurements were performed in addition to CO2 measurements and the precise kinetic of the DOC measurements was not provided).
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): obtained from influent of Saint-Germain au Mont d'Or STP treating domestic sewage.
- Storage length: used on day of preparation
- Pretreatment: coarse filtration, concentration by centrifugation and washed.
- Initial cell/biomass concentration: 3.8 E+07 bact./mL - Duration of test (contact time):
- 28 d
- Initial conc.:
- 40 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
KH2PO4: 85.000 mg
K2HPO4: 217.500 mg
NH4CI: 5.000 mg
Na2HPO4, 2H2O: 334.000 mg
MgSO4, 7 H2O: 22.500 mg
CaCl2, 2 H2O: 36.400 mg
FeCl3, 6 H2O: 0.250 mg
bidistilled water: 1000 g
- Test temperature: 22 ± 2 °C
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 2
SAMPLING
- Sampling frequency: 0, 1, 4, 5, 8, 11, 12, 15, 22 and 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2
- Abiotic sterile control: 1
- Toxicity control: 1
- Reference control: 1 - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 100
- Sampling time:
- 18 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- ca. 50
- Sampling time:
- 28 d
- Remarks on result:
- other: Due to the uncertainty associated with the use of a biological reagent, the final value is presented close to 50%.
- Details on results:
- Remarks on the results obtained with the CO2 measurements:
The difference of biodegradation between the two flasks containing the substance at the end of the test is not more than 20% (41% and 52% after 28 days). More than 25% of biodegradation was obtained within 14 days in the inhibitory flask (61% of biodegradation after 15 days). No inhibitory effect was observed.
No abiotic degradation was observed in the flask containing the test medium, the substance and the biocide NaN3.
Remarks on the results obtained with the DOC measurements:
The difference of biodegradation between the two flasks containing the substance at the end of the test is less than 20% (99.8% and 100% after 18 days). 95.7% of biodegradation was obtained within 18 days days in the inhibitory flask. No inhibitory effect was observed. No significant abiotic degradation was observed in the flask containing the test medium, the substance and the biocide NaN3 (10.2% of degradation after 18 days). - Results with reference substance:
- CO2 measurements: Less than 60% of biodegradation was reached within 14 days in the control flask containing sodium acetate (58% of biodegradation after 15 days). Nevertheless the level of 72% of biodegradation was reached at the end of the test.
DOC measurements: More than 70% of biodegradation was reached within 18 days in the control flask containing sodium acetate (93.5% of biodegradation after 18 days). - Validity criteria fulfilled:
- not specified
- Conclusions:
- The ready biodegradabilitay of 3-(Mehylthio)propionaldehyde was investigated in a study conducted according to ISO9439 guideline (1990, method by analysis of the carbon dioxide released). Mesurements of the dissolved organic carbon (DOC) were performed in addition to the CO2 measurements. CO2 evolution reached 50% in 28 days. As DOC was shown to be 100% eliminated in 18 days in inoculated test vessels, and 10% in sterile vessels, the DOC removal was concluded to be biotic.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-10-27 to 1999-11-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- Version / remarks:
- 29. December 1992
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): obtained from influent of Saint-Germain au Mont d'Or STP treating domestic sewage.
- Storage length: used on day of preparation
- Pretreatment: coarse filtration, concentration by centrifugation and washed.
- Initial cell/biomass concentration: 7.7 E+066 bact./mL - Duration of test (contact time):
- 28 d
- Initial conc.:
- ca. 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
KH2PO4: 85.000 mg
K2HPO4: 217.500 mg
NH4CI: 5.000 mg
Na2HPO4, 2 H2O: 334.000 mg
MgSO4, 7 H2O: 22.500 mg
CaCl2, 2 H2O: 36.400 mg
FeCl3, 6 H2O: 0.250 mg
bidistilled water: 1000 g
- Test temperature: 20.7 °C - 22.8 °C
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 0.5 L - Erlenmeyer flasks
- Number of culture flasks/concentration: 2
SAMPLING
- Sampling frequency: 0, 2, 6, 8, 14, 19, 21 and 28 days
- Sampling method: culture medium was mixed before samples was taken. Samples were filtered before analysis (0.22 µm)
- Sample storage before analysis: directly after sampling or storage at 4 °C for max. 48 h
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2
- Abiotic sterile control: 1
- Toxicity control: 1
- Other: reference control: 1 - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 92
- St. dev.:
- 1
- Sampling time:
- 28 d
- Details on results:
- Remarks: The difference of biodegradation between the two flasks containing the substance at the end of the test is less than 20%
.
More than 35% of biodegradation was obtained within 14 days in the inhibitory flask (81% of biodegradation after 14 days). No inhibitory effect was observed.
No abiotic degradation was observed in the flask containing the test medium, the substance and the biocide NaN3. - Results with reference substance:
- More than 70% of biodegradation was reached within 14 days in the control flask containing sodium acetate (92% of biodegradation after 14 days) confirming the activity of the inoculum.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance was degraded by 92% after 28 days under testing conditions. Thus, the substance is readily biodegradable according to the OECD criteria.
Referenceopen allclose all
Description of key information
The test substance is readily biodegradable (92% after 28 days, DOC Die-Away Test).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The key study on the ready biodegradability of the substance was conducted according to EU Method C.4-A. The degradation rate of the substance was determined by measuring the DOC removal during an incubation period of 28 days. The substance was incubated with activated sludge taken from a STP treating domestic sewage. Based on the dissolved organic carbon (DOC) removal a degradation of 92% was determined after 28 days. The 10-day window criterion was met. Thus, the substance is readily biodegradable according to OECD criteria.
Two additional studies testing the biodegradation of the substance are available. In a guideline study according to guideline ISO DIS 9439 the biodegradation of the substance was determined by measuring the CO2 evolution as well as the DOC content. Based on the DOC removal a degradation of 100% after 18 days was determined. The measurement of CO2 evolution resulted in a degradation of ca. 50% after 28 days.
A study performed according to guideline DIN 38409-51 and DIN38409-41 respectively investigated the biodegradation based on the biological oxygen demand (BOD) after 5 days and chemical oxygen demand (COD). The average BOD5 was 600 mg/g of the test substance. The average COD after 2 h of reaction was 1500 mg/g of the test substance. Since the BOD5/COD-ratio is 0.4 (trigger: 0.5) the substance cannot be classified as readily biodegradable.
In conclusion the substance is readily biodegradable.
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