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EC number: 221-882-5 | CAS number: 3268-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01-11-26 - 02-02-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- Cited as Directive 92/69/EEC, C.7
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- - pH: 4
Standard-buffer-solution pH 4. Bernd Kraft GmbH. Art.-No.: 03083.3000
- pH: 7
Standard-buffer-solution pH 7. Bernd Kraft GmbH. Art.-No.: 03086.3000
- pH: 9
Standard-buffer-solution pH 9. Riedel-de Haen. Art.-No.: 33548 - Details on test conditions:
- TEST SYSTEM (Prelimenary test)
- Type, material and volume of test flasks, other equipment used: HPLC vials
- Measures taken to avoid photolytic effects: vials were protected from light
- If no traps were used, is the test system closed/open: performed in closed HPLC vials
TEST MEDIUM
- Volume used/treatment: 100 mL
- Kind and purity of water: Reagent water generated by the Millipore system "Milli Q"
- Preparation of test medium: Amounts of the test substance were weighed exactly into volumetric flasks (100 mL). The test substance was dissolved and subsequently adjusted to the mark using the corresponding buffer solution.
TEST SYSTEM (Main test)
- Type, material and volume of test flasks, other equipment used: HPLC vials
- Measures taken to avoid photolytic effects: vials were protected from light
- If no traps were used, is the test system closed/open: performed in closed HPLC vials
TEST MEDIUM
- Volume used/treatment: 100 mL
- Kind and purity of water: Reagent water generated by the Millipore system "Milli Q"
- Preparation of test medium: 82.32 mg of the test substance were weighed into a 100 mL volumetric flask and filled up to the mark with standard buffer solution. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 759.5 mg/L
- Remarks:
- Preliminary test
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 606.5 mg/L
- Remarks:
- Preliminary test
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 562.3 mg/L
- Remarks:
- Preliminary test
- Duration:
- 101 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 782.08 mg/L
- Remarks:
- Main test
- Duration:
- 5 890 min
- pH:
- 7
- Temp.:
- 55 °C
- Initial conc. measured:
- 624.57 mg/L
- Remarks:
- Main test
- Duration:
- 3 060 min
- pH:
- 7
- Temp.:
- 65 °C
- Initial conc. measured:
- 645.03 mg/L
- Remarks:
- Main test
- Duration:
- 580 min
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 757.19 mg/L
- Remarks:
- Main test
- Duration:
- 3 055 min
- pH:
- 9
- Temp.:
- 39 °C
- Initial conc. measured:
- 639.21 mg/L
- Remarks:
- Main test
- Number of replicates:
- 2 replicates
- Positive controls:
- no
- Negative controls:
- yes
- Preliminary study:
- After 5 days less than 10% had been hydrolysed. The determined degradation of the substance at pH 4 and 50 °C corresponded to a half-life time of more than one year under outdoor conditions. The determined half-life at pH 7 and pH 9 at 50 °C was > 2.4 d. Thus, in accordance with EU method C.7, the main test was performed at pH 7 and pH 9 only.
- Transformation products:
- not measured
- % Recovery:
- 64.44
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 101 h
- % Recovery:
- 58.28
- pH:
- 7
- Temp.:
- 55 °C
- Duration:
- 98.17 h
- % Recovery:
- 48.03
- pH:
- 7
- Temp.:
- 65 °C
- Duration:
- 51 h
- % Recovery:
- 31.78
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 9.7 h
- % Recovery:
- 20.98
- pH:
- 9
- Temp.:
- 39 °C
- Duration:
- 50.92 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: determined in preliminary test
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 75.4 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated from results at 50 - 65 °C
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.004 h-1
- DT50:
- 6.5 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated from results at 50 and 39 °C
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes - Validity criteria fulfilled:
- not applicable
- Conclusions:
- The half-life time at pH 7 and 25 °C was extrapolated from the measured values at 50, 55 and 65 °C. The half-life time was 1810 h (appr. 75 days).
The half-life time at pH 9 and 25 °C was extrapolated from the measured values at 50 and 39 °C. The half-life time was 156 h (appr. 6.5 days).
Reference
Description of key information
DT50: appr. 75 days at pH 7 and 25 °C
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 75 d
- at the temperature of:
- 25 °C
Additional information
The hydrolysis of the substance was tested in a study following Directive 92/69/EEC, C.7 (GLP). A preliminary test was set up testing the hydrolysis at pH 4, 7 and 9 at a temperature of 50 °C. An extrapolation of the results for pH 4 and 50 °C resulted in a half-life > 1 year under environmentally relevant conditions. The determined half-life at pH 7 and pH 9 at 50 °C was > 2.4 days. Thus, in accordance with EU method C.7, the main test was performed at pH 7 (50, 55 and 65 °C ) and pH 9 (50 °C, 39 °C) only. From the results in the main test a half-life of appr. 75 days was extrapolated for pH 7 and 25 °C. For pH 9 and 25 °C a half-life of appr. 6.5 days was extrapolated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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