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Diss Factsheets
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EC number: 221-490-4 | CAS number: 3118-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from EFSA journal and IARC monograph.
- Objective of study:
- excretion
- metabolism
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Metabolism and excretion of the target substance 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol was studied in rats.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- no data
- Duration and frequency of treatment / exposure:
- no data
- Remarks:
- not specified
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Positive control reference chemical:
- no data
- Details on study design:
- no data
- Details on dosing and sampling:
- no data
- Statistics:
- no data
- Type:
- metabolism
- Results:
- Th dye was easily reduced by intestinal bacteria to 1-amino-2naphthyl sulphate and eight 8 other metabolites, five of whch were red-coloured
- Type:
- excretion
- Results:
- excreted in urine
- Metabolites identified:
- yes
- Details on metabolites:
- 1-amino-2naphthyl sulphate and 8 other metabolites (name not specified)
- Conclusions:
- The dye 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is said to be easily reduced by intestinal bacteria, after gavage administration to rats in corn oil 1-amino-2naphthyl sulphate and 8 other metabolites were excreted in urine.
- Executive summary:
The dye 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is said to be easily reduced by intestinal bacteria, after gavage administration to rats in corn oil 1-amino-2naphthyl sulphate and 8 other metabolites were excreted in urine.
Reference
Description of key information
Basic toxicokinetics:
The dye 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is said to be easily reduced by intestinal bacteria, after gavage administration to rats in corn oil 1-amino-2naphthyl sulphate and 8 other metabolites were excreted in urine.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Basic toxicokinetics:
Two studies of the target substance 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol were reviewed for basic toxicokinetics endpoint, as cited in The EFSA Journal (2005) 263, 1-71, and are presented below as weight of evidence approach:
In key study, the dye 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is said to be easily reduced by intestinal bacteria, after gavage administration to rats in corn oil 1-amino-2naphthyl sulphate and 8 other metabolites were excreted in urine.
Other study indicates that after 14C-labelled Sudan II (1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol) was administered, 86% of the activity was found in the faeces with only 14% in the urine and 11 metabolites were identified, but these are not specified in the review.
Based on the above studies and by applyiing weight of evidence approach it can be concluded that majority of the test substance 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is easily metabolised and excreted in urine and faeces, so the substance shows no bioaccumulation potential inside the body.
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