Registration Dossier
Registration Dossier
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EC number: 221-329-8 | CAS number: 3068-78-8
Endpoint summary
Administrative data
Description of key information
Additional information
N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) hydrolyses rapidly (4.1 min at pH 7 and 25 °C) to N-[3-(trihydroxysilyl)propyl]cyclohexanamine and methanol. The hydrolysis is even faster at pH 4 and 9 with half-lives of 2.6 min and << 2 min, respectively (EU Method C.7). Taking the rapid hydrolysis half-life at pH 7 into account, the environmental hazard assessment for the aquatic compartment, including waste water treatment plant is based on the properties of the hydrolysis product instead of the parent substance in accordance with REACH guidance for Chemical Safety Assessment R.16 (ECHA, 2016).
The substance is not considered readily biodegradable (29% within 28 d taking nitrification into account, OECD 301F) based on read across from N-{[Diethoxy(methyl)silyl]methyl}cyclohexanamine (CAS 27445-54-1).
The silanol hydrolysis product of N-[3-(trimethoxysilyl)propylcyclohexylamine] is very water soluble (1.0E+06 mg/L at 20-25 °C) bears a low volatility (1.3E-06 Pa at 25 °C) and a low potential for adsorption given by the low log Kow value of -0.1. These physicochemical parameters indicate that the silanol hydrolysis product will mainly distribute in the water column.
The physicochemical parameters and environmental fate of the other hydrolysis product methanol are well known and described in the SIDS initial assessment report for SIAM 19: Methanol (OECD 2004).
Reference:
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.
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