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EC number: 215-475-1 | CAS number: 1327-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not irritating to the skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
In vitro
There is no data available for aluminatesilicate. Therefore a read-across was conducted from structurally related substances. The skin irritation potential of silicic acid, aluminium salt was determined by Paulus (2010, in vitro, RL2) according to OECD guideline (Draft proposal for a new guideline. In vitro skin irritation: human skin model test, Dezember, 2007). Approx. 25 mg of the test item were applied to EpiDermTM tissues. After 35 minutes incubation tissues were rinsed and incubated for further 42 hours. The cell viability was measured photometric by dehydrogenase conversion of MTT. No decrease of cell viability was detected compared to the negative control. Under these test conditions the substance has no skin irritation potential.
In vivo
Five-tenths of a gram of kaolin clay polydimethylsiloxane as 50% (w/w) mixture in distilled water was applied to the skin of New Zealand rabbits (Engelhard Corp., 1997, RL2). The study was performed according to OECD guideline 404 under GLP-conditions. The observation period was 72 hours instead of 14 days, but no dermal irritation was noted. The primary dermal irritation index was 0.
No skin irritation potential of aluminatesilicate is expected.
Eye irritation
There is only an in vitro study available for the evaluation of aluminatesilicate. Available in vivo data for Surround WP Crop Protectant is considered to be data of structurally related substance with similar toxicological properties.
In vitro The eye irritancy potential of aluminatesilicate was screened by using the Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) test following ICCVAM recommended test method protocol dated November 2006 (Paulus and Andres, 2010, RL1). 0,3 mL of the powdery test item were added pure to the membrane of 6 nine day incubated Lohmann Leghorn chicken eggs. The reactions on the CAM were observed over a period of 300 seconds.
Aluminatesilicate showed no effects on the blood vessels of the CAM. The calculated mean irritation score was 0.00. Under these experimental conditions aluminatesilicate possesses no irritation potential.
In vivo
Surround WP Crop Protectant was tested in a primary eye irritation study in rabbits (Engelhard Corp., 2000, RL2). The test substance was instilled into the conjunctival sac of the right eye of one male and two female rabbits without washing off. One hour following test substance instillation, all three treated eyes exhibited conjunctivitis. The overall incidence and severity of irritation decreased thereafter. All animals were free of ocular irritation by 48 hours.
Respiratory irritation
No data available.
Justification for classification or non-classification
Skin
Based on read-across data there is no need for classification.
Eye
There is conclusive data available which is not sufficient for classification.
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