Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-674-4 | CAS number: 366-18-7
Endpoint summary
Administrative data
Description of key information
One skin irritation study as well as a skin application study are available:
K.S.Williamson (1972), none guideline skin irritation study (rat): severe erythema after 24 h
Swan (1958), none guideline skin irritation study (rat): mild erythema after repeated exposure
Furthermore, observations from acute dermal toxicity studies are available:
K.S.Williamson (1972), Acute dermal toxicity study (rat): severe erythema after 24 h, diminishing over 6 days
S.L.Allen & J.E.Barber (1987), Acute dermal toxicity study (rat): signs of moderate skin irritation
Two studies on eye irritation are available:
K.S.Williamson (1972), non-guideline eye irritation study (rat): inconclusive
Swan (1958), non-guideline study eye irritation study (rat): Not Irritant
The data on skin and eye irriation are too weak to make a conclusion on irritating effects of 2,2'-bipyridine. No data exists to assess respiratory irritation.
Key value for chemical safety assessment
Additional information
Based on the study outline in the various study reports on skin irriation as well as acute dermal toxicity, a conclusion on the irritating effects of the test item to the skin cannot be drawn due to the significantly prolonged exposure time.
Justification for classification or non-classification
Based upon the classification criteria according to regulation (EC) No 1272/2008 of the European Parliment and of the Council of 16 December 2008, classification of the test item for skin irritation is inconclusive.
Based upon the classification criteria according to regulation (EC) No 1272/2008 of the European Parliment and of the Council of 16 December 2008, classification of the the test item for eye irritation is inconclusive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
