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EC number: 205-771-9 | CAS number: 150-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 range by oral route: 3600 - 8500 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No enough details. Documentation is insufficient for assessment.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other:
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Species: rat
- Strain: no data
- Sex: no data
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: Average weight of animals:
- group tested at 1000 mg: 175 g
- group tested at 1250 mg: 172 g
- group tested at 1500 mg: 176 g
- group tested at 1750 mg: 130 g.
- Fasting period before study: no data
- Housing: no data
- Food consumption: no data
- Water consumption: no data
- Acclimation period: no data
Environmental conditions: no data
In-life dates: no data - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Maximum dose volume applied: 1750 mg
- Dosage preparation (if unusual): no data
- Rationale for the selection of the starting dose: no data - Doses:
- 1000; 1250; 1500; 1750 mg corresponding to 5714 mg/kg, 7267 mg/kg, 8522 mg/kg and 13461 mg/kg.
- No. of animals per sex per dose:
- for doses of 1000, 1250 and 1500 mg, 10 animals per dose.
For dose of 1750 mg, only one animal.
Sex unspecified. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- examinations performed: other: no data - Statistics:
- no data
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 500 mg/kg bw
- Mortality:
- 2/10 died at dose of 1000 mg (5714 mg/kg), whereas, 5/10 died at dose of 1500 mg (8522 mg/kg). One rat treated at dose of 1750 mg/kg, died.
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to EU and UN GHS criterias, the substance is not classified for acute oral toxicity.
- Executive summary:
In a oral acute study, rats were exposed to 5714 mg/kg, 7267 mg/kg, 8522 mg/kg and 13461 mg/kg of the test substance. The LD50 is 8500 mg/kg. Based on this value, the substance is not classified for acute oral toxicity.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Unpublished RIFM report. No details were done on the experimental study.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Species: rat
- Strain: no data
- Sex: no data
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: no data
- Food consumption: no data
- Water consumption: no data
- Acclimation period: no data
Environmental conditions: no data
In-life dates: no data - Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- 2560; 3200; 4000; 5000 mg/kg
- No. of animals per sex per dose:
- 10 (sex unspecified)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- examinations performed: other: no data - Statistics:
- no data on statistical method used for calculation of LD50
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 600 mg/kg bw
- 95% CL:
- 3 130 - 4 070
- Mortality:
- 2560 mg/kg lethal, 3 deaths.
3200 mg/kg lethal, 4 deaths.
4000 mg/kg lethal, 6 deaths.
5000 mg/kg lethal, 10 deaths. - Clinical signs:
- other: Toxic signs were lethargy and loss of righting reflex.
- Gross pathology:
- no data
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- According to EU GHS criteria, the substance is considered not classified for acute oral toxicity.
According to UN GHS criteria, the substance is classified Acute. Tox. Cat. 5, H303. - Executive summary:
In an acute toxic class method study, rats were exposed to 2560, 3200, 4000 and 5000 mg/kg of 1,4 -dimethoxybenzene (PDMB). The LD50 calculated is 3600 mg/kg (95% CL: 3130 - 4070 mg/kg). Based on this result, the substance is not classified according to EU GHS criteria.
Referenceopen allclose all
The doses were not indicated in mg/kg bw but only in mg. The LD50 was calculated in accordance with weight of animals.
2560 mg/kg lethal, 3 deaths, Lethargy.
3200 mg/kg lethal, 4 deaths, Lethargy.
4000 mg/kg lethal, 6 deaths, Lethargy.
5000 mg/kg lethal, 10 deaths. Toxic signs were lethargy and loss of righting reflex.
3600 mg/kg calculated LD50, 95% limits=3130-4070 mg/kg.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Oral:
Two studies, one with reliability 3 and one with reliability 4 according to Klimisch were available. As the LD50 in rats was in the range from 3600 to 8500 mg/kg, no key study was chosen and a "Weight of Evidence" approach was applied.
Dermal:
Only one unpublished study from RIFM was available. As it was with reliability 4, no purpose flag was chosen. The result gave a LD50 above 5000 mg/kg.
Justification for classification or non-classification
Based on two studies used in a WOE approach, the LD50 in rats was in the range from 3600 to 8500 mg/kg. Based on this range, the substance is not classified for acute oral toxicity according to EU GHS criteria and classified Acute. Tox. Cat. 5, H303 according to UN GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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