Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-524-2 | CAS number: 122-14-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies are presented and none are required. Data on the toxicokinetic properties of fenitrothion are taken from the 2006 EFSA Scientific Report.
Fenitrothion (FNT) is rapidly and almost completely absorbed. It is mainly distributed to the liver, blood and carcass. Elimination is very rapid. The main metabolites are the phosphate fenitrothion (FNO), the mono methyl analogues of FNT and FNO (DM-FNT and DM-FNO respectively) and 3methyl-4-nitrophenol (NMC) and its corresponding sulphate and glucuronide.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 20.9
- Absorption rate - inhalation (%):
- 100
Additional information
Absorption, distribution, excretion and metabolism in mammals
Rate and extent of absorption
Rapid and almost complete oral absorption (86–100 % in urine after 7 days after a low or high dose).
Dermal absorption 3.9% (concentrate) and 20.9% (dilution) for a microencapsulated product; a value of 20% is used for risk assessment purposes.
Inhalation absortion assumed to be 100% (default).
Distribution
Well distributed into organs and tissues. Liver>>whole blood>residual carcass after low dose
Potential for accumulation
Limited potential
Rate and extent of excretion
Rapid; 88-99.8 % in urine within 24 hours after a low dose
Metabolism
Extensively metabolised. No parent recovered in urine of rats, mice, rabbits and dogs. Primarily conjugates of parent, fenitrothion and conjugates and 3-methyl-4-nitrophenol and conjugates
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
