2-(2-pyridyl)ethanol

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001-07-24 - 2001-10-17

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: well-documented GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method C.1 (Acute Toxicity for Fish)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

The Department of the Health of the Government of the United Kingdom

Test material

Test material information

Constituent 1

Reference substance name:

Pyridine-2-ethanol

IUPAC Name:

Pyridine-2-ethanol

Details on test material:

- Physical state: liquid
- Lot/batch No.: 1280031
- Storage condition of test material: Room temperature, in the dark until 31 July 2001, thereafter approximately 4ºC in the dark.

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:

semi-static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Basis for effect:

mortality (fish)

Any other information on results incl. tables

Sublethal observations / clinical signs:

There were no mortalities in 20 fish exposed to a test concentration of 100 mg/L for a period of 96 hours. Inspection of the mortality data gave the following results:

 

Time (h)                                LC50(mg/L)                     95% Confidence limits (mg/L)

----------------------------------------------------------------------------------------------------------

3                                          >100                                -

6                                          >100                                -

24                                         >100                                -

48                                         >100                                -

72                                         >100                                -

96                                         >100                                -

 

The results of the definitive study showed the highest test concentration resulting in 0% mortality to be greater than or equal to 100 mg/L, the lowest test concentration resulting in 100% mortality to be greater than 100 mg/L and the No Observed Effect Concentration (NOEC) to be 100 mg/L.

It was considered unnecessary and unrealistic to test at concentrations in excess of 100 mg/L.

There were no sub-lethal effects of exposure observed in 20 fish exposed to a test concentration of 100 mg/L for a period of 96 hours. The test preparations were observed to be clear colourless solutions throughout the definitive study.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The acute toxicity of the test material to the freshwater fish rainbow trout (Oncoryhnchus mykiss) has been investigated and gave a 96-Hour LC50 of greater than 100 mg/L. Correspondingly the No Observed Effect Concentration was 100 mg/L.