Registration Dossier
Registration Dossier
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EC number: 202-181-3 | CAS number: 92-71-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24th July 2017 to the 20th November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 2,5-diphenyloxazole
- EC Number:
- 202-181-3
- EC Name:
- 2,5-diphenyloxazole
- Cas Number:
- 92-71-7
- Molecular formula:
- C15H11NO
- IUPAC Name:
- 2,5-diphenyl-1,3-oxazole
- Test material form:
- solid: crystalline
- Details on test material:
- Expiry date:01 February 2021
Storage conditions: Room temperature in the dark
Batch 21-16131
1
- Specific details on test material used for the study:
- Identification:
2,5-diphenyloxazole
Appearance/Physical state:
White crystalline powder
Batch:
21-16131
Purity:
99.9%
Expiry date:
01 February 2021
Storage conditions:
Room temperature, in the dark
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 4.1
- Temp.:
- 30 °C
- pH:
- ca. 5.6
- Details on results:
- Mean log10 Pow: 4.10
Partition coefficient: 1.25 x 10^4
Applicant's summary and conclusion
- Conclusions:
- The substance, 2,5-diphenyloxazole, partition coefficient was studied in accordance with EC Method A.8 and OECD Method 117 via a GLP-certified laboratory. The study used the reverse HPLC method and determined that the substance partition coefficient (n-ocanol/water) to be 1.25 x 10^4, log10 Pow 4.10.
- Executive summary:
The substance, 2,5-diphenyloxazole, partition coefficient was studied in accordance with EC Method A.8 and OECD Method 117 via a GLP-certified laboratory. The study used the reverse HPLC method with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase. The resultant time to pass through the coloumn was compared to 6 different reference substances and then extrapulated for the true-value prior to substance dilution.
The study determined that the substance partition coefficient (n-ocanol/water) to be 1.25 x 10^4, log10 Pow 4.10.
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