p-menthane-1,8-diol

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 November 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted according to OECD 109 and EU A.3 guidelines, under GLP without deviation and with certificate of analysis included.

Reason / purpose for cross-reference:

reference to other study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Remarks:

2021-03-17

Type of method:

pycnometer method

Key result

Type:

relative density

Density:

1 048.2 kg/m³

Temp.:

20 °C

Remarks on result:

other: Mean of trial 2 and 3

Type:

relative density

Density:

1 058.5 kg/m³

Temp.:

20 °C

Remarks on result:

other: Trial 1

Type:

relative density

Density:

1 049.6 kg/m³

Temp.:

20 °C

Remarks on result:

other: Trial 2

Type:

relative density

Density:

1 046.7 kg/m³

Temp.:

20 °C

Remarks on result:

other: Trial 3

Results of three determinations are reported in the following table:

 

Identification	Determination	1	2	3
Weights (g)	m0	31.43954	31.62077	31.14233
	m1	81.48810	81.64330	81.26210
	m2	81.49450	81.64960	81.27050
	m3	36.59294	36.76520	36.74753
	m4	81.78740	81.90100	81.52950
Calculation	V (mL)	50.139	50.113	50.210
	mx (g)	50.055	50.029	50.128
	ρx (g/mL)	0.99833	0.99833	0.99837
	me (g)	5.15340	5.14443	5.60520
	me+x (g)	50.34786	50.28023	50.38717
	ρe (g/mL)	1.05849	1.04962	1.04673
Pycnometer volume	Vcontrol	50.19898	50.17287	50.27040

 

Determinations 2 and 3 have the closest results (0.28% of difference). Their arithmetic mean is 1048.2 kg/m3 at 20.0 +/- 0.1°C. The corresponding relative density of the test item is D204 = 1.048
Moreover, the pycnometer volumes Vcontrol calculated for each pycnometer respects their checking cards limits and the bath used to maintain the pycnometer at 20.0°C did not vary by more than 0.1°C.

 

Conclusions:

The density of the test item P-MENTHANE-1,8-DIOL was determined to be 1048.2 kg/m3 at 20.0 +/- 0.1°C (mean of two determinations).
The relative density of the test item was determined to be D204 = 1.048

Executive summary:

A study was performed to determine the density of the test item P-MENTHANE-1,8-DIOL. The method followed was designed to be compliant with the OECD Guideline for Testing of Chemicals No. 109, "Density of Liquids and Solids"(2012) and the Method A.3 of Commission Regulation No. 440/2008, “Relative Density”

In this method, the density is determined at a specific temperature using a pycnometer.
A saturated solution of the test item is prepared in water, petroleum or any solvent in which the substance is sparingly soluble and does not react.
The weights of the pycnometer empty and filled successively with water and saturated solution are taken. A certain amount of test item is then added in the pycnometer and weighted. It is then completed with saturated solution and weighted again.
These weights allow to determine the density.

 

Determination  Density (kg/m^3) at 20.0 +/-0.1°C  1 1058.5  2 1049.6 3 1046.7  Mean of determinations 2 and 3 1048.2

 

Validity criteria (less than 1% of difference) is respected between the couple of values 1-2 and 2-3. The two determinations with the closest results (2 and 3) were taken into account and their arithmetic mean is considered as the result of the experiment.
Moreover, the pycnometer volumes Vcontrol calculated for each pycnometer respects their checking cards limits and the bath used to maintain the pycnometer at 20.0°C did not vary by more than 0.1°C.

The density of the test item was determined to be 1048.2 kg/m3 at 20.0 +/- 0.1°C (mean value of determinations 2 and 3).
The relative density of the test item was determined to be D204 = 1.048

 

Description of key information

Study conducted according to OECD 109 and EU A.3 guidelines, under GLP without deviation and with certificate of analysis included.

Key value for chemical safety assessment

Relative density at 20C:

1.048