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Diss Factsheets
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EC number: 200-090-3 | CAS number: 51-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the physicochemical properties of the substance indicate that it can be expected to have a low potential for adsorption
- Justification for type of information:
- Scopolamine, is a tertiary amine having a pKa of 7.75 and therefore a medium-strong, organic base. This means that the substance is present predominately as cation in the environmental relevant range pH 6 to pH 8. Scopolamine has a low octanol-water partition coefficient (Log Kow 1.31) and is very soluble in water (29.82 g/L at 20°C). Using the Log Kow of 1.31, a adsorption coefficient of Log Koc 1.288 was calculated. Based on these physico-chemical properties, and with the substance is considered to be inherently biodegradable, fulfilling specific criteria, Scopolamine when released in the environment is expected to mainly partition in water phase. This is also supported by its predicted log Koc of 1.288 indicating that Scopolamine is mobile in soil. Thus, no further testing is considered necessary.
Reference
Description of key information
The study does not need to be conducted because the substance has a low octanol water partition coefficient (Log Kow 1.31 at 20°C and pH 9), is very soluble in water (29.82 g/L at 20°C) and is inherently biodegradable, fulfilling specific criteria. Based on the data available, no further testing is considered necessary. However, for PNEC calculation a Koc of 19.4 was calculated according to Di Toro, 1985 ( A particle interaction model of reversible organic chemical sorption; Chemosphere 14(10):1503-1538).
Calculation formula: Adsorption coefficient per organic carbon (Koc): log Koc = 0.00028 + (0.983 x log Kow).
Key value for chemical safety assessment
- Koc at 20 °C:
- 19.4
Additional information
[LogKoc: 1.288]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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