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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01 June 2018 to 07 June 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study was conducted in accordance with international guidelines and in accordance with GLP
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Date of Inspection: 18 July 2017 - 20 July 2017 Date on Certfiicate: 28 November 2017
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
25 °C
Vapour pressure:
< 0.003 Pa

Recorded temperatures, mass differences and the resulting calculated values of vapor pressure are shown in the following tables:

Run 5

Table 1 - Vapour Pressure Data

Temperature (°C)

Temperature (K)

Reciprocal Temperature (K­-1)

Mass difference (µg)

Mass difference (kg)

Vapor Pressure (Pa)

Log­10Vp

85

358.15

0.002792

6.09

6.090e-09

0.00845

-2.07314

86

359.15

0.002784

5.89

5.890e-09

0.00818

-2.08725

87

360.15

0.002777

6.69

6.690e-09

0.00929

-2.03198

88

361.15

0.002769

8.89

8.890e-09

0.01234

-1.90868

89

362.15

0.002761

5.99

5.990e-09

0.00832

-2.07988

90

363.15

0.002754

5.99

5.990e-09

0.00832

-2.07988

91

364.15

0.002746

6.19

6.190e-09

0.00859

-2.06601

92

365.15

0.002739

6.79

6.790e-09

0.00943

-2.02549

93

366.15

0.002731

6.59

6.590e-09

0.00915

-2.03858

94

367.15

0.002724

6.39

6.390e-09

0.00887

-2.05208

95

368.15

0.002716

6.99

6.990e-09

0.00970

-2.01323

No statistical analysis is given due to the nature of the plot.

Run 6

Table 2 - Vapour Pressure Data

Temperature (°C)

Temperature (K)

Reciprocal Temperature (K­-1)

Mass difference (µg)

Mass difference (kg)

Vapor Pressure (Pa)

Log­10Vp

85

358.15

0.002792

4.99

4.990e-09

0.00693

-2.15927

86

359.15

0.002784

4.89

4.890e-09

0.00679

-2.16813

87

360.15

0.002777

6.59

6.590e-09

0.00915

-2.03858

88

361.15

0.002769

6.19

6.190e-09

0.00859

-2.06601

89

362.15

0.002761

5.69

5.690e-09

0.00790

-2.10327

90

363.15

0.002754

6.99

6.990e-09

0.00970

-2.01323

91

364.15

0.002746

6.49

6.490e-09

0.00901

-2.04528

92

365.15

0.002739

6.59

6.590e-09

0.00915

-2.03858

93

366.15

0.002731

5.79

5.790e-09

0.00804

-2.09474

94

367.15

0.002724

5.69

5.690e-09

0.00790

-2.10237

95

368.15

0.002716

6.99

6.990e-09

0.00970

-2.01323

No statistical analysis is given due the nature of the plot.

Run 7

Table 3 - Vapour Pressure Data

Temperature (°C)

Temperature (K)

Reciprocal Temperature (K­-1)

Mass difference (µg)

Mass difference (kg)

Vapor Pressure (Pa)

Log­10Vp

85

358.15

0.002792

6.79

6.790e-09

0.00943

-2.02549

86

359.15

0.002784

5.89

5.890e-09

0.00818

-2.08725

87

360.15

0.002777

5.69

5.690e-09

0.00790

-2.10237

88

361.15

0.002769

9.58

9.580e-09

0.01330

-1.87615

89

362.15

0.002761

8.09

8.090e-09

0.01123

-1.94962

90

363.15

0.002754

7.19

7.190e-09

0.00998

-2.00087

91

364.15

0.002746

12.48

1.248e-08

0.01733

-1.76120

92

365.15

0.002739

10.18

1.018e-08

0.01414

-1.84986

93

366.15

0.002731

9.98

9.980-09

0.01385

-1.85855

94

367.15

0.002724

8.89

8.890e-09

0.01234

-1.90868

95

368.15

0.002716

9.49

9.490e-09

0.01317

-1.88041

No statistical analysis is given due to the nature of the plot.

Run 8

Table 4 - Vapour Pressure Data

Temperature (°C)

Temperature (K)

Reciprocal Temperature (K­-1)

Mass difference (µg)

Mass difference (kg)

Vapor Pressure (Pa)

Log­10Vp

85

358.15

0.002792

8.19

8.190e-09

0.01137

-1.94424

86

359.15

0.002784

8.49

8.490e-09

0.01179

-1.92849

87

360.15

0.002777

7.09

7.090e-09

0.00984

-2.00700

88

361.15

0.002769

6.99

6.990e-09

0.00970

-2.01323

89

362.15

0.002761

6.09

6.090e-09

0.00845

-2.07314

90

363.15

0.002754

7.09

7.090e-09

0.00984

-2.00700

91

364.15

0.002746

7.39

7.390e-09

0.01026

-1.98885

92

365.15

0.002739

7.79

7.790e-09

0.01081

-1.96617

93

366.15

0.002731

8.59

8.590e-09

0.01993

-1.92336

94

367.15

0.002724

8.20

8.290e-09

0.01151

-1.93892

95

368.15

0.002716

7.49

7.490e-09

0.01040

-1.98297

No statistical analysis is given due to the nature of the plot

Discussion

The test item did not change in appearance under the conditions used in the determination.

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapor pressure at 25 °C.

Run 8 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 86 °C (355.15 K) was chosen because this is the data point which gives the highest estimated vapor pressure at any given temperature when a slope of –1000 K is imposed upon it.

The value of –1000 K is an in-house value and is the shallowest slope observed whilst determining the vapor pressure on a wide range of samples using the vapor pressure balance method. Extrapolation to 25 °C gave a vapor pressure of 3.17 xE-03 Pa which has been taken as a maximum for this material.

Conclusions:
The vapor pressure of the test item has been determined to be less than 3.2E-03 Pa at 25 °C.
Executive summary:

The vapor pressure of α-phenyl-1H-benzimidazole-2-methanol has been determined to be less than 3.2 x 10-3 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Description of key information

The vapour pressure of α-phenyl-1H-benzimidazole-2-methanol has been determined to be less than 3.2 x10-3Pa.

Key value for chemical safety assessment

Vapour pressure:
0.003 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of α-phenyl-1H-benzimidazole-2-methanol has been determined to be less than 3.2E-3 at 25 °C, using the vapour pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

As the maximum vapour pressure 3.2E-3 Pa has been selected as the key value for the purposes of the chemical safety assessment only.