Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
202-966-0
CAS no.:
101-68-8
Index number:
615-005-00-9
Molecular formula:
C15H10N2O2
SMILES:
O=C=NC1=CC=C(CC2=CC=C(C=C2)N=C=O)C=C1
InChI:
InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
28
Of which contain:
5 impurities relevant for classification
2 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic if inhaled and may cause damage to organs.

Breakdown of all 1918 C&L notifications submitted to ECHA

Resp. Sens. 1 H334 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
Carc. 2 H351 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Acute Tox. 3 H331
STOT SE 2 H371
STOT SE 3 H370
Skin Irrit. 2 H314
Acute Tox. 2 H330
Muta. 2 H341
STOT RE 1 H372
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 55 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants and coating products.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: adhesives and sealants and coating products.

This substance is used in the following areas: building & construction work, health services and printing and recorded media reproduction. This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, roller or brushing applications, non-industrial spraying, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, treatment of articles by dipping and pouring and the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: coating products, inks and toners, polymers and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, laboratory work, batch processing in synthesis or formulation with opportunity for exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles.

This substance is used in the following products: adhesives and sealants, coating products and polymers.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, mixing in open batch processes, closed, continuous processes with occasional controlled exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, in the production of articles, in processing aids at industrial sites, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates) and formulation in materials.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; wear respiratory protection; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If exposed or concerned: get medical advice/attention. If on skin: wash with soap and water. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF Italia S.p.A., Via Marconato 8 20811 Cesano Maderno Italy
  • BASF Polyurethanes GmbH, Elastogranstr. 60 49448 Lemförde Niedersachsen Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BorsodChem, Bolyai ter 1 3700 Kazincbarcika Hungary
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • Caplinq Europe B.V., Industrieweg 15E 1566JN Assendelft - Netherlands
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Chemservice S.A. (H5P7), 13, Fausermillen 6689 Mertert Luxembourg
  • Chemservice S.A. (TZ6C), 13, Fausermillen 6689 Mertert Luxembourg
  • COIM SpA, Via delle Azalee, 19 20090 Buccinasco (MI) Italy
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR CN_001554, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR JP_000145, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR US_001257, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • COVESTRO, S.L., C/. Feixa LLarga, 7 08040 Barcelona Spain
  • CSI-OR52DUB, CSI-Europe Block C Ardilaun Court, 112-114 St. Stephen’s Green D02 TD28 Dublin Ireland
  • Delrin Netherlands B.V., Baanhoekweg 22 3313 Dordrecht Netherlands
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • FujiFilm Manufacturing Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Huntsman (Europe) BV - OR2, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman (Europe) BV - OR8, Everslaan 45 B-3078 Everberg Belgium
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • Jowat SE, Ernst-Hilker-Str. 10 - 14 32758 Detmold NRW Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 19, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 30, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 33, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Mitsubishi_Chemical_Europe_GmbH, Schiessstraße 47 40549 Düsseldorf Germany
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • Nesperta sp. z o.o. , Rejtana 12 A 62-030 Luboń Poland
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • Ramboll Deutschland GmbH, Werinherstraße 79 Gebäude 32a 81541 München Bayern Germany
  • Ravago Chemicals Netherlands BV, Neptunusstraat 15 2132 JA Hoofddorp Netherlands
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • SAINT-GOBAIN INNOVATIVE MATERIALS BELGIUM SA, AVENUE EINSTEIN 6 1300 WAVRE Belgium
  • Specialty Electronic Materials Netherlands BV OR-1, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • TSE, OR for NPU, Amstelplein 1 1096 HA Amsterdam Netherlands
  • W. L. Gore & Associates GmbH, Hermann-Oberth-Strasse 22 85640 Putzbrunn Germany
  • Yordas GmbH, Äußere Nürnberger Str. 62, 91301 Forchheim Germany
  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany
  • Lohmann & Rauscher GmbH & Co. KG, Irlicher Straße 55 56567 Neuwied Germany
  • Renishaw PLC, New Mills GL12 8JR Wotton-under-Edge Gloucestershire United Kingdom
  • SLM Solutions Group AG, Estlandring 4 23560 Lübeck Germany
  • W. L. Gore & Associates (UK) Ltd., Kirkton South Road Kirkton Campus EH54 7BT Livingston United Kingdom

Substance names and other identifiers

4,4'-Diphenylmethane diisocyanate
Other
4,4'-methylenediphenyl diisocyanate
EC Inventory, REACH pre-registration
4,4'-Methylenediphenyl diisocyanate
REACH pre-registration, Cosmetic Products Regulation, Annex II - Prohibited Substances
4,4'-methylenediphenyl diisocyanate diphenylmethane-4,4'-diisocyanate
C&L Inventory
4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
4,4’-Methylenediphenyl diisocyanate
Restriction list, Substance Evaluation - CoRAP
diphenylmethane-4,4'-diisocyanate
FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
4,4'-methyleendifenyldiisocyanaat difenylmethaan-4,4'-diisocyanaat (nl)
C&L Inventory
4,4'-methylendifenyl diisokyanát difenylmethan-4,4'-diisokyanát (cs)
C&L Inventory
4,4'-methylendiphenyldiisocyanat diphenylmethan-4,4'-diisocyanat (da)
C&L Inventory
4,4'-Methylendiphenyldiisocyanat Diphenylmethan-4,4'-diisocyanat (de)
C&L Inventory
4,4'-metilendifenil diizocianat difenilmetan-4,4'-diizocianat (sl)
C&L Inventory
4,4'-metiléndifenil-diizocianát difenilmetán-4,4'-diizocianát (hu)
C&L Inventory
4,4'-metilēndifenildiizocianāts difenilmetāna-4,4'-diizocianāts (lv)
C&L Inventory
4,4'-Metyleenidifenyylidi-isosyanaatti difenyylimetaani-4,4'-di-isosyanaatti (fi)
C&L Inventory
4,4'-metylendifenyldiisocyanat difenylmetan-4,4'-diisocyanat (no)
C&L Inventory
4,4'-metylendifenyldiisocyanat difenylmetan-4,4'-diisocyanat (sv)
C&L Inventory
4,4'-metyléndi(fenylizokyanát) difenylmetán-4,4'-diizokyanát (sk)
C&L Inventory
4,4'-metüleendifenüüldiisotsüanaat difenüülmetaan-4,4'-diisotsüanaat (et)
C&L Inventory
4,4'-метилендифенил диизоцианат дифенилметан-4,4'-диизоцианат (bg)
C&L Inventory
4,4′-metilendifenildiizocianatas difenilmetan-4,4′-diizocianatas (lt)
C&L Inventory
diisocianato de 4,4'-metilendifenilo diisocianato de 4,4'-difenilmetano (es)
C&L Inventory
diisocianato de 4,4'metilenodifenilo 4,4'-diisocianato de difenilmetano (pt)
C&L Inventory
diisocianato di 4,4'-metilendifenile difenilmetan-4,4'-diisocianato (it)
C&L Inventory
diisocyanate de 4,4'-méthylènediphényle; diphénylméthane-4,4'-diisocyanate; 4,4'-diisocyanate de diphénylméthane (fr)
C&L Inventory
diizocianat de 4,4'-metilen-difenil 4,4'-diizocianat de difenil-metan (mt)
C&L Inventory
diizocianat de 4,4'-metilen-difenil difenilmetan-4,4'-diizocianat (ro)
C&L Inventory
diizocyjanian 4,4'-metylenodifenylu) 4,4'-metylenobis(fenyloizocyjanian) bis(4-diizocyjanianofenylo)metan (pl)
C&L Inventory
διισοκυανικό 4,4'-μεθυλενοδιφαινύλιο διισοκυανικό 4,4'-διφαινυλομεθάνιο (el)
C&L Inventory
1,1'-methanediylbis(4-isocyanatobenzene)
C&L Inventory
1,1'-methylenebis(4-isocyanatobenzene)
C&L Inventory, Registration dossier
1,1’-methylenebis(4-isocyanatobenzene)
Registration dossier
1-isocyanato-4-(4-isocyanatobenzyl)-benzeen
C&L Inventory
1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene
C&L Inventory
1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
C&L Inventory, Registration dossier, Other
4,4 - methylenediphenyl diisocyanate
C&L Inventory
4,4 methylenediphenyldiisocyanate
C&L Inventory
4,4' MDI
Registration dossier
4,4'-DIISOCIANATO DE DIFENIL-METILENO
C&L Inventory
4,4'-Diisocyanatodiphenylmethane
C&L Inventory
4,4'-DIPHENYLMETHANE DIISOCYANATE
C&L Inventory
4,4'-diphenylmethane diisocyanate
C&L Inventory, Registration dossier
4,4'-MDI
Registration dossier
4,4'-Methylendiphenyl diisocyanate
C&L Inventory
4,4'-Methylenediphenyl diisocyanate
C&L Inventory, Registration dossier
4,4'-Methylenediphenyl diisocyanate
C&L Inventory, Registration dossier
Benzene, 1,1'-methylenebis[4-isocyanato-
C&L Inventory
difenylmethan-4,4'-diisokyanát
C&L Inventory
Diisocyanate of 4,4 '-methylenediphenyl
C&L Inventory
Diphenylmethane diisocyanate
C&L Inventory
DIPHENYLMETHANE-4,4'-DI-ISOCYANATE
C&L Inventory
diphenylmethane-4,4'-diisocyanate
C&L Inventory
Diphenylmethane-4,4'-diisocyanate
C&L Inventory
Diphenylmethane-4,4'-diisocyanate (MDI)
C&L Inventory
MDI
Registration dossier
MDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI,
Registration dossier
MDI, MMDI, Pure MDI, Rein MDI, 4,4`-MDI
Registration dossier
Methylene diphenyl diisocyanate
C&L Inventory
Methylenediphenyl 4,4'-Diisocyanate
C&L Inventory
1,1'-methylenebis(4-isocyanatobenzene)
Registration dossier
1,1`-methylenebis(4-isocyanatobenzene)
Registration dossier
4,4'-Diisocyanatodiphenylmethane
Registration dossier
4,4'-Diphenylmethane diisocyanate
Registration dossier
4,4'-MDI
Registration dossier
4,4'-Methylenebis(isocyanatobenzene)
Registration dossier
4,4'-Methylenebis(phenyl isocyanate)
Registration dossier
4,4'-Methylenebis(phenylisocyanate)
Registration dossier
4,4'-Methylenediphenyldiisocyanate
Registration dossier
4,4'Methylendi-p-phenylenediisocyanate
Registration dossier
4,4`-Diisocyanatodiphenylmethane
Registration dossier
4,4`-MDI
Registration dossier
4,4`-Methylenebis(phenyl isocyanate)
Registration dossier
4,4`-Methylenedi-p-phenylenediisocyanate
Registration dossier
4,4`-Methylenediphenyldiisocyanate
Registration dossier
4,4`-Methylenediphenylene isocyanate
Registration dossier
4,4´-Diphenylmethane diisocyanate
Registration dossier
4,4´-Methylenebis(isocyanatobenzene)
Registration dossier
Benzene, 1,1'-methylenebis(4-isocyanato-(9CI))
Registration dossier
Benzene, 1,1`-methylenebis(4-isocyanato-(9CI)
Registration dossier
Bis(1,4-isocyanatophenyl)methane
Registration dossier
Bis(4-isocyanatophenyl)methane
Registration dossier
Bis(p-isocyanatophenyl)methane
Registration dossier
Desmodur 44 M
Registration dossier
Di(4-isocyanatophenyl)methane
Registration dossier
Diphenylmethane 4,4`-diisocyanate
Registration dossier
Diphenylmethane diisocyanate
Registration dossier
Diphenylmethane-4,4'-diisocyanate
Registration dossier
Diphenylmethanediisocyanate
Registration dossier
Diphenylmethylene diisocyanate
Registration dossier
Diphenymethane-4,4'-diisocyanate
Registration dossier
isocyanaic acid, methylene di-p-phenyleneester(6CI,8CI)
Registration dossier
Isocyanic acid, diphenylmethylene ester
Registration dossier
Isocyanic acid, methylenedi-p-phenylene ester (6CI, 8CI)
Registration dossier
Isocyanic acid, methylenedi-p-phenylene ester (6CI,8CI)
Registration dossier
ISONATE* M124
Registration dossier
ISONATE* M125
Registration dossier
ISONATE* M125 M
Registration dossier
MDI
Registration dossier
methylene-di-p-phenylene diisocyanate
Registration dossier
Methylenebis(4-isocyanatobenzene)
Registration dossier
Methylenebis(4-phenyl isocyanate)
Registration dossier
Methylenebis(4-phenylene isocyanate)
Registration dossier
Methylenebis(p-phenyl isocyanate)
Registration dossier
Methylenebis(p-phenylene isocyanate)
Registration dossier
Methylenebis-p-phenylene diisocyanate
Registration dossier
Methylenebisphenylene diisocyanate
Registration dossier
Methylenebisphenylenediisocyanate
Registration dossier
Methylenedi-p-phenylene diisocyanate
Registration dossier
Methylenedi-p-phenylene isocyanate
Registration dossier
Name
Registration dossier
p,p'-Diphenylmethane diisocyanate
Registration dossier
p,p'-Methylenebis(phenyl isocyanate)
Registration dossier
p,p`-Diphenylmethane diisocyanate
Registration dossier
p,p`-Methylenebis(phenyl isocyanate)
Registration dossier
SS-001
C&L Inventory
4,4'-Diphenylmethane diisocyanate
REACH pre-registration
4,4'-methylenediphenyl diisocyanate
REACH pre-registration
Benzene, 1,1'-methylenebis[4-isocyanato-
REACH pre-registration
101-68-8
CAS number
EC Inventory, C&L Inventory, Restriction list, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
1211266-59-9
CAS number
Other
1211316-64-1
CAS number
Other
1220313-65-4
CAS number
Other
1400594-70-8
CAS number
Other
142690-07-1
CAS number
Other
1533423-48-1
CAS number
Other
153986-89-1
CAS number
Other
1588489-56-8
CAS number
Other
201528-77-0
CAS number
Other
2031250-39-0
CAS number
Other
2056146-02-0
CAS number
Other
53633-14-0
CAS number
Other
55157-41-0
CAS number
Other
57460-66-9
CAS number
Other
615-005-00-9
Index number
C&L Inventory
77090-48-3
CAS number
Other
88001-94-9
CAS number
Other
97568-33-7
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
39 - 43 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
42 °C

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
300 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
1.18 g/cm³ @ 50 °C [1]
R Relative density
1.32 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.32

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
0.001 - 0.183 Pa @ 20 - 70 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0.001 Pa @ 20 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 1 study processed
R Log Pow
4.51 @ 22 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
30 µg/L @ 22 °C

Solubility in organic solvents / fat solubility

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
211 °C @ 100 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 1 study processed
R Autoflammability / self-ignition
601 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 3 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
8 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
8 h

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
5 min @ 20 °C

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Not biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
24 h @ 22 °C

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
200

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 3.7 µg/L (1)
Intermittent releases (freshwater) 37 µg/L (1)
Marine water 370 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) 11.7 mg/kg sediment dw (1)
Sediment (marine water) 1.17 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 2.33 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LL50 (4 days) 100 mg/L [1]
LL0 (4 days) 100 mg/L [1]
LL100 (4 days) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EL50 (48 h) 9 mg/L [1]
EL0 (48 h) 4.3 mg/L [1]
EL100 (48 h) 45.5 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 10 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EL10 (72 h) 100 mg/L [1]
EL50 (72 h) 100 mg/L [1]
NOELR (72 h) 100 mg/L [1]
LOELR (72 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
100 mg/L
EC10 or NOEC for freshwater algae
100 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 1 g/L [1]
NOEC (3 h) 250 mg/L [1]
EC10 (3 h) 260 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 50 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 100 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 25 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 50 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 25 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 14 1 1 1
Weight of evidence
Other 6
Data waiving
no waivers
Study data: dermal absorption
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 3
Data waiving
no waivers
inhalation
  • 9 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 367.95 - 558.98 mg/m³ air (rat) [4]
M/CInterpretations of results
Other [1]

inhalation
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other 3
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
Adverse effect observed LC50 431 mg/m³ air

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LOAEC (rat): 230 µg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 4 1
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
Adverse effect observed NOAEC 1 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 200 µg/m³ (chronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 4 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant