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Diss Factsheets
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EC number: 945-327-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- Silicon dioxide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- hydrophilic SAS, tradename Ultrasil VN3, purity 98%
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Total exposure duration:
- 24 h
Results and discussion
Effect concentrations
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- ca. 1 000 - ca. 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- not determinable
- Details on results:
- With the water flea (Daphnia magna), SAS suspensions exceeding the limit of solubility were tested, without analysis during the 24 hours of exposure, and some immobilisation was observed. However, no significant immobilisation was observed when a solution filtered through microfibre glass filter was tested. The observed effects were likely caused by physical hampering of the Daphnia due to the presence of undissolved particles. In ecotoxicity assays, the tested concentrations should normally not exceed the limit of solubility of the substance and should not affect the test system (Method C2 - Annex V of Directive 67/548/CEE [EC, 1967]). Therefore the immobilisation of Daphnia, obtained with turbid suspensions, cannot be considered as a true toxic effect of SAS.
Applicant's summary and conclusion
- Conclusions:
- With the water flea (Daphnia magna), SAS suspensions exceeding the limit of solubility were tested, without analysis during the 24 hours of exposure, and some immobilisation was observed. However, no significant immobilisation was observed when a solution filtered through microfibre glass filter was tested. The observed effects were likely caused by physical hampering of the Daphnia due to the presence of undissolved particles. In ecotoxicity assays, the tested concentrations should normally not exceed the limit of solubility of the substance and should not affect the test system (Method C2 - Annex V of Directive 67/548/CEE [EC, 1967]). Therefore the immobilisation of Daphnia, obtained with turbid suspensions, cannot be considered as a true toxic effect of SAS.
- Executive summary:
With the water flea (Daphnia magna), SAS suspensions exceeding the limit of solubility were tested, without analysis during the 24 hours of exposure, and some immobilisation was observed. However, no significant immobilisation was observed when a solution filtered through microfibre glass filter was tested. The observed effects were likely caused by physical hampering of the Daphnia due to the presence of undissolved particles. In ecotoxicity assays, the tested concentrations should normally not exceed the limit of solubility of the substance and should not affect the test system (Method C2 - Annex V of Directive 67/548/CEE [EC, 1967]). Therefore the immobilisation of Daphnia, obtained with turbid suspensions, cannot be considered as a true toxic effect of SAS.
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