[2-(2-methoxyethoxy)ethoxy]acetic acid

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-04-20 to 2018-02-08

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Specific details on test material used for the study:

Purity: 97.5 %
Batch No.: 08/2016_R_JM

Key result

Temp.:

20 °C

Vapour pressure:

0.017 Pa

Temp.:

25 °C

Vapour pressure:

0.031 Pa

Observations

30 °C: At the first measurement of experiment 1 the weight loss was too high. As this can be caused by impurities with a higher vapour pressure (like water), these values were not used for calculation.

90 °C: All cells were empty. After enough value data, the test was stopped. The high weight loss of the first measurement is a sign of impurities (like water) with a higher vapour pressure. To avoid bias these values were not used for calculation.

Experimental results

T	T	P	Stand. Dev. P	RSD P
°C	K	Pa	Pa	%
30.0	303.2	5.97E-02	1.19E-02	19.9%
45.0	318.2	2.79E-01	6.18E-02	22.2%
60.0	333.2	1.38	7.91E-02	5.7%
75.0	348.2	5.94	1.34	22.5%

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:	1.65E-2Pa
Vapour pressure at 25 °C:	3.07E-2Pa

The linear regression of log P vs. 1/T gave a correlation coefficient r of - 0.9995, showing good repeatability and precision. Therefore, the determination is considered as valid.

The vapour pressure of the positive control met the validity criteria. Therefore, the study can be considered as valid.

Vapour pressure (positive control) at 30 °C:	2.03E-1 Pa
Criteria for the vapour pressure of the positive control at 30 °C	1.44E-1 ± 0.1 Pa

Conclusions:

The vapour pressure of the test item was estimated, based on the experimental results, to be 1.65E-2 Pa at 20 °C and 3.07E-2 Pa at 25 °C, respectively.

Executive summary:

The vapour pressure of the test item was determined at four different temperatures (30, 45, 60 and 75 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). As the cells were empty at the highest tested temperature (90 °C), therefore, the determination was finished. Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 23 % and good correlation. Therefore, the result of the test can be considered as valid. The vapour pressure of the test item was estimated, based on the experimental results, to be 1.65E-2 Pa at 20 °C and 3.07E-2 Pa at 25 °C, respectively.

Description of key information

The vapour pressure of the test item was estimated, based on the experimental results, to be 1.65E-2 Pa at 20 °C and 3.07E-2 Pa at 25 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:

0.017 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of the test item was determined at four different temperatures (30, 45, 60 and 75 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). As the cells were empty at the highest tested temperature (90 °C), therefore, the determination was finished. Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 23 % and good correlation. Therefore, the result of the test can be considered as valid. The vapour pressure of the test item was estimated, based on the experimental results, to be 1.65E-2 Pa at 20 °C and 3.07E-2 Pa at 25 °C, respectively.