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EC number: 819-688-6 | CAS number: 219828-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: no study conducted
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Oct 2012 - 09 Oct 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: Japanese White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kitayama Labes Co. Ltd
- Age at study initiation: 21 weeks
- Weight at study initiation: 3.81 kg
- Housing: metal bracket-type cages (350 W x 500 D x 350 H, mm)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 10 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3°C
- Humidity (%): 44 - 60%
- Air changes (per hr): 8 -13 per hour
- Photoperiod (hrs dark / hrs light): 12 hours light
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL/section
- Concentration (if solution): according to test guideline
VEHICLE
- Amount(s) applied: 0.5mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hr, 24 hr, 48 hr, 72 hr, and 4 days
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with cotton swab soaked with tepid water
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
- 1 hr, 24 hr, 48hr, 72hr, 4 days
SCORING SYSTEM: macroscopic observation of the skin
- Method of calculation: according to the globalyl harmonised system of classification and labelling of chemicals (GHS) criteria for skin corrosion/irritation - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 0 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48hr, 72hr, 4 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 0 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1hr, 24,hr, 48hr, 72hr, 4 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- At the sites treated with Methyl 2-(Allyloxymethyl)Acrylate, very slight erythema (score 1) accompanied by very slight oedema (score 1) was noted immediately after patch removal.
This irritative change worsened over time, and severe erythema (beet-redness) to eschar formation preventing grading of erythema (score 4) accompanied by severe oedema (score 4), indicating hemorrhagic eschar, was noted by 72 hours after patch removal.
This change was also found 4 days after patch removal.
Methyl 2-(Allyloxymethyl)Acrylate was classified as category 1 according to the the GHS criteria for skin irritation/corrosion.
On the basis of these results, it was concluded that Methyl 2-(Allyloxymethyl)Acrylatehas skin corrosion potential.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A Skin Irritation/ Corrosion study (Safety Research Institute for Chemical Compounds, 2013, Study SR12174) was conducted to determine the skin corrosion potential of 2-(Allyloxymethyl) acrylic acid methyl ester. The study was performed according to OECD test guideline 404 and in compliance with GLP.
The effects of dermal exposure to 2-(Allyloxymethyl) acrylic acid methyl ester were investigated in one New Zealand White rabbit. A single occlusive application of 2-(Allyloxymethyl) acrylic acid methyl ester for four hours elicited a dermal reaction ranging from well-defined to moderate to severe in the animal tested. No further animals were tested based on the reaction to 2-(Allyloxymethyl) acrylic acid methyl ester after the first testing. Very slight erythema (score 1) accompanied by very slight oedema (score 1) was noted immediately after patch removal at all sites tested with 2-(Allyloxymethyl) acrylic acid methyl ester. This irritative change got worse over time. Severe erythema (beet-redness) to eschar formation preventing grading of erythema (score 4) accompanied by severe oedema (score 4) was observed 48 and 72 hours after patch removal. This change was noted also noted 4 days after patch removal.
On the basis of this observation 2-(Allyloxymethyl) acrylic acid methyl ester is considered to be corrosive to skin and meets the criteria for classification as corrosive to skin.
According to Commission Regulation 1272/2008 table 3.2.1 CLP Annex I, 2-(Allyloxymethyl) acrylic acid methyl ester meets category 1.
An Eye Irritation study was not conducted to assess the effect of the instillation of 2-(Allyloxymethyl) acrylic acid methyl ester on the basis that it was found to have a skin corrosion potential
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: no study conducted
Justification for classification or non-classification
On the basis of the above studies, 2-(Allyloxymethyl) acrylic acid methyl ester meets the criteria for classification as corrosive to skin.
According to Commission Regulation 1272/2008, 2-(Allyloxymethyl) acrylic acid methyl ester is classified as corrosive to skin, Category 1; the related Signal word is "Danger", and the Hazard Statement is "H314: Causes severe skin burns and eye damage".
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