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Diss Factsheets
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EC number: 907-961-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- According to Draize J H (1959). Appraisal of the safety of chemicals in foods, drugs and cosmetics. Association of Food and Drug Officials of the US, 49.
A single four-hour application was made to the left flank and a total of three four-hour applications, on consecutive days, was made to the right flank. - GLP compliance:
- no
Test material
- Reference substance name:
- Tridecyl methacrylate
- EC Number:
- 219-671-8
- EC Name:
- Tridecyl methacrylate
- Cas Number:
- 2495-25-2
- Molecular formula:
- C17H32O2
- IUPAC Name:
- tridecyl methacrylate
- Reference substance name:
- Dodecyl methacrylate
- EC Number:
- 205-570-6
- EC Name:
- Dodecyl methacrylate
- Cas Number:
- 142-90-5
- Molecular formula:
- C16H30O2
- IUPAC Name:
- dodecyl methacrylate
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2404-2879 g
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 3 d
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: shorn dorso-lumbar region, 2.5 cm²
single applications (left flank)
repeated applications (right flank): The repeated-application sites were assessed approximately 30-60 minutes after the removal of the dressings following each application and 1, 2, 3, 7, 9 and 14 days after removal of the dressings following the final application.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): On removal of the dressings, the skins were cleansed with clean warm water.
OBSERVATION TIME POINTS
30-60 min, 1, 2, 3 days
SCORING SYSTEM:
- Method of calculation: Draize scale (Draize 1959),
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 2 days
- Irritation parameter:
- erythema score
- Basis:
- animal: #2-6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1-6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Single Application: Very slight or moderate to severe erythema was observed in five rabbits 30-60 minutes after decontamination. Very slight erythema was observed in one rabbit one day after decontamination. All
signs of erythema had disappeared two days after decontamination. Very slight or slight oedema was observed in four rabbits 30-60 minutes after decontamination. All signs of oedema had disappeared one day after
decontamination.
Repeated Applications: Repeated (x3) four-hour applications of the undiluted test sample to rabbit skin caused moderate to severe erythema in all six rabbits during the application phase and one, two and three days after decontamination of the final application. All signs of erythema had disappeared seven days after decontamination of the final application. Slight to severe oedema was observed in all six rabbits during the application phase and one day after decontamination of the final application. Slight to severe oedema was observed in four rabbits two days after decontamination of the final application; one rabbit had thickening obscuring any oedema. Moderate or severe oedema was still observed in three rabbits three days after decontamination of the final application.
All signs of oedema had disappeared seven days after decontamination of the final application.
Additional signs of irritation were desquamation, thickening and hardening. - Other effects:
- One animal was killed during the study but its illness was not thought to be compound-related.
Any other information on results incl. tables
Single exposure
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 4 |
|
60 min |
3/1/0/1/1/1 |
1/0/0/2/1/2 |
24 h |
1//00/0/0/0 |
0/0/0/0/0/0 |
48 h |
0/0/0/0/0/0 |
0/0/0/0/0/0 |
72 h |
0/0/0/0/0/0 |
0/0/0/0/0/0 |
Average 24h, 48h, 72h |
0.3/0/0/0/0/0 |
0/0/0/0/0/0 |
Reversibility |
Completely reversible within 48 h |
Not applicable |
Repeated exposures (3)
Animal number |
Erythema |
Edema |
||||
Number of applications |
Number of applications |
|||||
1 |
1 |
2 |
1 |
2 |
3 |
|
1 |
2 |
2 |
4 |
0 |
1 |
2 |
2 |
1 |
1 |
2 |
0 |
0 |
2 |
3 |
0 |
1 |
3 |
0 |
1 |
3 |
4 |
2 |
2 |
4 |
2 |
4 |
4 |
5 |
1 |
2 |
4 |
1 |
1 |
4 |
6 |
1 |
3 |
4 |
2 |
2 |
4 |
Animal number |
Erythema |
Edema |
||||||||||
Days after final application |
Days after final application |
|||||||||||
1 |
2 |
3 |
7 |
9 |
14 |
1 |
2 |
3 |
7 |
9 |
14 |
|
1 |
4 |
4 |
2 |
- |
- |
- |
2 |
2 |
0 |
- |
- |
- |
2 |
3 |
2 |
2 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
0 |
0 |
3 |
2 |
2 |
3 |
0 |
0 |
0 |
3 |
3 |
3 |
0 |
0 |
0 |
4 |
4 |
4 |
4 |
0 |
0 |
0 |
4 |
4 |
4 |
0 |
0 |
0 |
5 |
4 |
4 |
2 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
6 |
4 |
4 |
3 |
0 |
0 |
0 |
4 |
? |
3 |
0 |
0 |
0 |
- animal killed, therefore, no observation made
? thickening obscuring possible oedema
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Reaction mass of dodecyl methacrylate and tridecyl methacrylate was not irritating to skin in this study.
- Executive summary:
In a primary dermal irritation study 6 female young adult New Zealand White rabbits were dermally exposed to 0.5 mL of undiluted Reaction mass of dodecyl methacrylate and tridecyl methacrylate for 4 hours. Animals then were observed for 3 days. Irritation was scored by the method of Draize.
Very slight or moderate to severe erythema was observed in five rabbits 30-60 minutes after decontamination. Very slight erythema was observed in one rabbit one day after decontamination. All signs of erythema had disappeared two days after decontamination. Very slight or slight oedema was observed in four rabbits 30-60 minutes after decontamination. All signs of oedema had disappeared one day after decontamination.
Additionally, the substance was applied in three repeated 4 hours exposures. Repeated (x3) four-hour applications of the undiluted test sample to rabbit skin caused moderate to severe erythema in all six rabbits during the application phase and one, two and three days after decontamination of the final application. All signs of erythema had disappeared seven days after decontamination of the final application. Slight to severe oedema was observed in all six rabbits during the application phase and one day after decontamination of the final application. Slight to severe oedema was observed in four rabbits two days after decontamination of the final application; one rabbit had thickening obscuring any oedema. Moderate or severe oedema was still observed in three rabbits three days after decontamination of the final application. All signs of oedema had disappeared seven days after decontamination of the final application. Additional signs of irritation were desquamation, thickening and hardening.
Reaction mass of dodecyl methacrylate and tridecyl methacrylate is not classified as skin irritant based on the results of this study according to the GHS criteria.
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