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EC number: 402-010-4 | CAS number: 4463-59-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-(2-bromoethoxy)-2-methoxybenzene
- EC Number:
- 402-010-4
- EC Name:
- 1-(2-bromoethoxy)-2-methoxybenzene
- Cas Number:
- 4463-59-6
- Molecular formula:
- C9H11BrO2
- IUPAC Name:
- 1-(2-bromoethoxy)-2-methoxybenzene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: S&K-LAP Kft., address: 2173, Kartal, Császár út 135, Hungary
- Age at study initiation: 11 weeks old
- Weight at study initiation: 2680-2740 g
- Housing: Animals were housed individually in metal cage
- Diet (e.g. ad libitum): The animals received C.HYF rabbit mixed diet produced by Cargill Takarmány Zrt., 5300 Karcag, Madarasi út 0399, Hungary, ad libitum.
- Water (e.g. ad libitum): The animals received C.HYF rabbit mixed diet produced by Cargill Takarmány Zrt., 5300 Karcag, Madarasi út 0399, Hungary, ad libitum.
- Acclimation period: 5 days in first animal, 6 days in second animal and 7 days in third animal
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3 °C
- Humidity (%): 30-70 %
- Air changes (per hr):above 10 air exchanges/hour by central air-condition system
- Photoperiod (hrs dark / hrs light): 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The contralateral eye served as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g of the test item was used for the study in undiluted form, as a single dose.
- Duration of treatment / exposure:
- The eyes of the test animals were not washed out 24 hour after test item application, because the test item had been removed from the eye of test animal by physiological mechanisms.
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
The eyes of the test animals were not washed out 24 hour after test item application, because the test item had been removed from the eye of test animal by physiological mechanisms.
SCORING SYSTEM:
Draize (1979) and OECD 405 (02 October 2012)
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0 - 0.66
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Treated and control eyes were examined at 1, 24, 48 and 72 hours after the application.
One hour after treatment some hyperemic blood vessels (score 1) were observed in all animals. The swelling of the conjunctivae was different from normal (score 1) in animal No.: 4687.
24 hours after treatment some hyperemic blood vessels (score 1) were observed in all animals.
48 hours after treatment some hyperemic blood vessels (score 1) were observed in two animals (No.: 4687, 4682). Animal No.: 4691 became free of symptoms.
72 hours after treatment all animals were free of symptoms.
72 hours after the treatment the study was finished.
During the study the control eyes of animals were symptom-free.
Detailed eye irritation results are shown in Appendix I.
The animals’ individual mean scores (considering readings at 24, 48 and 72 hours after the treatment) were as follows:
cornea opacity : 0.00, 0.00, 0.00
iris : 0.00, 0.00, 0.00
redness : 0.66, 0.66, 0.33
chemosis : 0.00, 0.00, 0.00
discharge : 0.00, 0.00, 0.00
No systemic toxicity was observed on the day of the treatment and during the 3-day observation period. The body weight of animals corresponded to their species and age. Sign of pain and distress was not observed during the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritant
- Conclusions:
- In conclusion, test item Bromethoxy-qvajacol (CVD 21) applied to the rabbits' eye mucosa caused slight conjunctival irritant effects which was fully reversible within 72 hours.
According to the EC criteria for classification and labelling requirements for dangerous substances and preparations, the test item does not have to be classified and has no obligatory labelling requirement for eye irritation.
According to Regulation (EC) No. 1272/2008, the test item has not been classified into any category.
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