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EC number: 226-033-2 | CAS number: 5235-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- September 17, 1981 to October 1, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study methodology follwed was equivalent or similar to OECD TG 402 and in accordance with the Principles of Good Laboratory Practice (GLP)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-[3-(1-naphthylamino)propyl]morpholine
- EC Number:
- 226-033-2
- EC Name:
- 4-[3-(1-naphthylamino)propyl]morpholine
- Cas Number:
- 5235-82-5
- Molecular formula:
- C17H22N2O
- IUPAC Name:
- N-[3-(morpholin-4-yl)propyl]naphthalen-1-amine
- Reference substance name:
- Oleic acid
- EC Number:
- 204-007-1
- EC Name:
- Oleic acid
- Cas Number:
- 112-80-1
- Molecular formula:
- C18H34O2
- IUPAC Name:
- octadec-9-enoic acid
- Reference substance name:
- Solvent naphtha (petroleum), heavy arom.
- EC Number:
- 265-198-5
- EC Name:
- Solvent naphtha (petroleum), heavy arom.
- Cas Number:
- 64742-94-5
- Molecular formula:
- not applicable
- Test material form:
- liquid
- Details on test material:
- Commercial Product
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: H.A.R.E. - Rabbits for Research, Hewitt, N.J.
- Age at study initiation: young adults
- Weight at study initiation: 2.0 - 4.0 kg
- Housing: individually housed
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): as per standard recommendations
- Humidity (%): as per standard recommendation
- Air changes (per hr): as per standard recommendation
- Photoperiod (hrs dark / hrs light): as per standard recommendation
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Shortly before dosing, the fur was clipped from the dorsal trunk area of each rabbit with electric clippers. During this procedure, care was taken to avoid accidental abrasion to the skin. The clipped area constituted constituted approximately 10% of the total body surface of each animal. Immediately after application, the trunk of each animal was wrapped with an occlusive binder. This consisted of a layer of plastic wrap, a protective cloth and a stockinette sleev all secured in place with masking tape.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 3 male + 3 female rabbits
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for mortality and toxic signs frequently on the day of dosing and twice daily thereafter for 14 days (at least 5 hours apart). The animals were weighed and weights recorded prior to initiation of the study and on days 8 and 15 of the study.
- Necropsy of survivors performed: yes - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality noted
- Clinical signs:
- other: No clinical signs noted
- Gross pathology:
- No noteworthy findings were noted
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- As no mortality was noted in the acute dermal application study of Marker MP tested at the limit dose of 2000 mg/kg body weight in New Zealand White rabbits, Marker MP will not be classified for dermal toxicity.
- Executive summary:
The acute dermal toxicity potential of Marker MP was evaluated in New Zealand White rabbits and under the conditions of the study, no mortality was noted in any of the rabbits dermally exposed to the limit dose of 2000 mg/kg body weight. As per Guidance to Regulation (EC) No. 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, Marker MP will not be classified.
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