Registration Dossier
Registration Dossier
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EC number: 210-894-6 | CAS number: 625-45-6
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- other: publication [Smialowicz1991a]
- Title:
- Unnamed
- Year:
- 1 991
- Reference Type:
- other: publication [Smialowicz1991b]
- Title:
- Immunotoxicity of 2-methoxyethanol following oral administration in Fischer 344 rats
- Author:
- Smialowicz RJ, Riddle MM, Luebke RW, Copeland CB, Andrews D, Rogers RR, Gray LE, Laskey JW
- Year:
- 1 991
- Bibliographic source:
- Toxicol Appl Pharmacol., 109: 494-506.
Materials and methods
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
Constituent 1
Constituent 2
Results and discussion
Applicant's summary and conclusion
- Executive summary:
F344 rats received 10 consecutive daily oral doses of Methoxyacetic acid ranging from 25 to 400 mg/kg bw in several experiments with somewhat diverging dosing regimens. At 100 and 200 mg/kg bw, thymic involution was observed in the absence of body weight reduction; there was also a reduction of lympho-proliferative responses to mitogens (Con A, PHA and PWM). At 200 mg/kg bw, the in vitro generated cytotoxic T-lymphocyte response was reduced, whereas mixed lymphocyte reaction and NKA were unaffected. The PFC response to TNP-LPS was suppressed throughout all dose levels, while increased to SRBC at 50 mg/kgbw. TNP-LPS- and SRBC-immunised rats dosed with Methoxyacetic acid showed suppression of PFC responses at 100 or 200 mg/kg bw and 200 or 400 mg/kg bw, respectively. Phenotypic analysis of splenocytes revealed a small (3%) reduction in the percentage of W3/25-positive cells (i.e. CD4, helper/inducer cells). Spleen cellularity appeared to be unaffected. Interleukin-2 production was decreased in the 150mg/kg bw group (Smialowicz et al, 1991a/b).
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