Registration Dossier
Registration Dossier
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EC number: 259-097-5 | CAS number: 54322-33-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for the CAS 1561-92-8
- Author:
- EUROPEAN COMMISSION European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- EUROPEAN COMMISSION European Chemicals Bureau, 2000.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to USA Interagency Regulatory Liaison Group Testing Standards and Guidelines Work Group
- Principles of method if other than guideline:
- The ocular irritation potential of sodium methallyl sulphonate was assessed in rabbits according to USA Interagency Regulatory Liaison Group Testing Standards and Guidelines Work Group Guidelines
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- EC Number:
- 216-341-5
- EC Name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- Cas Number:
- 1561-92-8
- Molecular formula:
- C4H8O3S.Na
- IUPAC Name:
- sodium 2-methylprop-2-ene-1-sulfonate
- Reference substance name:
- sodium methallyl sulphonate
- IUPAC Name:
- sodium methallyl sulphonate
- Test material form:
- other: solid
- Details on test material:
- common name: sodium methallyl sulphonate
substance type: organic
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): sodium 2–methylprop–2–ene–1–sulphonate
- Molecular formula:C4H8O3S.Na
- Molecular weight : 158.152 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 24,48,72 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0.33
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Irritation index: 0.33/110
or as the mean of 6 animals at 24, 48 and 72 hours: cornea: 0.06, iris: 0.0, conjunctiva: redness: 0.5, chemosis: 0.3
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- In an eye irritation study in rabbits, the mean irritation score after 72 hours was 0.33/110.
Hence,sodium methallyl sulphonate can be considered not irritating to rabbit eyes. - Executive summary:
The ocular irritation potential of sodium methallyl sulphonate was assessed in rabbits according to USA Interagency Regulatory Liaison Group Testing Standards and Guidelines Work Group Guidelines. Sodium methallyl sulphonate was instilled into the eyes of 6 rabbits and observed for signs of irritation. The rabbitts were scored for sugns of irritation at 24,48 and 72 hours.The mean of 6 animals at 24, 48 and 72 hours was: cornea: 0.06, iris: 0.0, conjunctiva: redness: 0.5, chemosis: 0.3.
The mean irritation score after 72 hours was 0.33/110.
Hence,sodium methallyl sulphonate can be considered not irritating to rabbit eyes.
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