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EC number: 272-028-3 | CAS number: 68649-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Stearalkonium Chloride
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 1 990
- Bibliographic source:
- International Journal of Toxicology, Vol 1, Issue 2, pp. 57 – 69, 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize method
- Principles of method if other than guideline:
- To evaluate the primary dermal irritation potential according to Draize procedure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzyldimethyl(octadecyl)ammonium chloride
- EC Number:
- 204-527-9
- EC Name:
- Benzyldimethyl(octadecyl)ammonium chloride
- Cas Number:
- 122-19-0
- Molecular formula:
- C27H50ClN
- IUPAC Name:
- N-benzyl-N,N-dimethyloctadecan-1-aminium chloride
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:Stearalkonium Chloride
Molecular Formula: C27H50N.Cl
Molecular Weight:424.152 g/mol
Substance Type: Organic
Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:Stearalkonium Chloride
Molecular Formula: C27H50N.Cl
Molecular Weight:424.152 g/mol
Substance Type: Organic
Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml of 25%, 2.5%, and 1.25% solutions of the test chemical
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24, 72 hours
- Number of animals:
- not mentioned
- Details on study design:
- Details on study design
TEST SITE
- Type of wrap if used: The treated areas were covered with gauze and wrapped to keep the test material in contact with the skin and to decrease the rate of vaporization. The wrapping and test material were removed 24 hours following application.
SCORING SYSTEM:
The wrapping and test material were removed 24 hours following application and the sites examined and scored separately for erythema and edema at 24 and 72 hours. Primary dermal irritation indices were calculated according to the Draize procedure for 25%, 2.5%, and 1.25% concentrations of the material. The mean scores for 24- and 72-hour readings were averaged to determine the irritation index.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 6
- Remarks on result:
- other: for 25% solution
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 2.4
- Remarks on result:
- other: for 1.25% solution
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 1
- Remarks on result:
- other: for 2.5% solution
- Irritant / corrosive response data:
- Primary Dermal Irritation Indices were as follows - 6.0 = 25% solution, 2.4 = 1.25% solution, 1.0 = 2.5% solution
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Primary dermal irritation indices were calculated according to the Draize procedure for 25%, 2.5%, and 1.25% concentrations of Stearalkonium Chloride. Primary irritation indices were calculated to be 6.0, 2.4, and 1.0 for the 25%, 1.25%, and 2.5% solutions, respectively.
Based on the primary irritation indices, Stearalkonium Chloride can be considered as mild irritant to skin. - Executive summary:
The primary dermal irritation potential ofStearalkonium Chloride was evaluated according to Draize method. Adult rabbits were used for the study. 0.5 ml of 25%, 2.5%, and 1.25% solutions of the test chemical was applied to clipped areas of intact and abraded rabbit skin. The treated areas were covered with gauze and wrapped to keep the test material in contact with the skin and to decrease the rate of vaporization. The wrapping and test material were removed 24 hours following application. The sites were examined and scored separately for erythema and edema at 24 and 72 hours. Primary dermal irritation indices were calculated according to the Draize procedure for 25%, 2.5%, and 1.25% concentrations of the material. The mean scores for 24- and 72-hour readings were averaged to determine the irritation index. Primary irritation indices were calculated to be 6.0, 2.4, and 1.0 for the 25%, 1.25%, and 2.5% solutions, respectively.
Based on the primary irritation indices, Stearalkonium Chloride can be considered as mild irritant to skin.
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