Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-909-4 | CAS number: 1066-30-4
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on carcinogenicity do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and is therefore conclusive but not sufficient for classification.
Additional information
Two studies are available which investigated carcinogenicity of the source substance chromium picolinate monohydrate in rats and mice similar to OECD 451 and GLP (NTP, 2008). In male rats in the 2-year study, there was an exposure-related significant increase in the incidence of preputial gland adenoma at 10,000 ppm; the incidence exceeded the historical control ranges for feed studies and for all routes of exposure.
Although the increase in the incidence of preputial gland adenoma at 10,000 ppm appeared to be treatment-related, this increase was considered to be equivocal evidence of carcinogenic activity because of the lack of an exposure concentration-response, absence of increased incidences in neoplasms in the corresponding tissue in females, lack of progression to carcinoma, and lack of pre-neoplastic lesions. There were no biologically significant increases in the incidences of neoplasms in any other tissue in male rats, or in any tissue in female rats or male or female mice.
Since chromium tricetate is not genotoxic in vivo and the long-term studies in rodents have only revealed marginal and probably irrelevant neoplastic effects, there is no concern for carcinogenic activity by chromium triacetate.
Justification for selection of carcinogenicity via oral route endpoint:
Hazard assessment is conducted by means of read-across from a structural analogue/surrogate. The selected study is the most adequate and reliable study based on the identified similarities in structure and intrinsic properties between source and target substance and overall assessment of quality, duration and dose descriptor level (refer to the endpoint discussion for further details).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
