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Diss Factsheets
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EC number: 249-120-7 | CAS number: 28645-51-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on the test chemical.
- Author:
- D. McGinty et.al.
- Year:
- 2 011
- Bibliographic source:
- Food and Chemical Toxicology (2011)
- Reference Type:
- publication
- Title:
- Skin irritation assay of the test chemical
- Author:
- D. Belsito et.al
- Year:
- 2 011
- Bibliographic source:
- Food and Chemical Toxicology, 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize test or modified Draize test in rabbits
- Principles of method if other than guideline:
- Eye irritation study was conducted on rabbits to evaluate the irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Oxacycloheptadec-10-en-2-one
- EC Number:
- 249-120-7
- EC Name:
- Oxacycloheptadec-10-en-2-one
- Cas Number:
- 28645-51-4
- Molecular formula:
- C16H28O2
- IUPAC Name:
- oxacycloheptadec-10-en-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Ambrettolide
- Molecular formula : C16H28O2
- Molecular weight : 252.395 gram/mol
- Substance type: Organic
- Smiles : C1C=CCCCCCCOC(CCCCCC1)=O
- InChI : 1S/C16H28O2/c17-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-18-16/h1,3H,2,4-15H2/b3-1-
- Physical state: Liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Albino Rabbits were used
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.5%
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- 4 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: No data available
- % coverage: No data available
- Type of wrap if used: No data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available
SCORING SYSTEM: redness ,chemosis and discharge from eye
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- fully reversible within: day 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Day 1 readings showed scores of 1, 2, and 3 for redness and chemosis. Discharge was also noted in all three animals. These signs generally remained at day 2, subsided by day 3 and cleared by day 4. Cornea and iris were not involved and remained normal.
- Other effects:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Day 1 readings showed scores of 1, 2, and 3 for redness and chemosis respectively. Discharge was also noted in all three animals. These signs generally remained at day 2, subsided by day 3 and cleared by day 4. Cornea and iris were not involved and remained normal.
Hence, the test chemical can be considered to be not irritating to rabbit eyes. - Executive summary:
Draize test or modified Draize test in rabbits was performed to evaluate the toxic nature of the test chemical. The test compound was instilled into the rabbit eye at a concentration of 0.5%. Day 1 readings showed scores of 1, 2, and 3 for redness and chemosis respectively. Discharge was also noted in all three animals. These signs generally remained at day 2, subsided by day 3 and cleared by day 4. Cornea and iris were not involved and remained normal.
Hence, the test chemical can be considered to be not irritating to rabbit eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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