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EC number: 201-210-7 | CAS number: 79-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22-Oct-2009 to 08-Feb-2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- gas saturation method
Test material
- Reference substance name:
- RS-Pantolactone
- IUPAC Name:
- RS-Pantolactone
- Details on test material:
- Identification: RS-Pantolactone
Batch Number: Bx TL 00905003
Purity: 99.7 %
Appearance: Waxy Solid, white
Expiry Date
(as given by the sponsor): May 2011
Expiry Date
(handled at Harlan Laboratories): May 31, 2011
Storage Conditions: At room temperature at about 20 °C
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 15.1 °C
- Vapour pressure:
- 0.7 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 2 Pa
- Temp.:
- 34.9 °C
- Vapour pressure:
- 4.9 Pa
Any other information on results incl. tables
Based on a model calculation, the vapor pressure of RS-Pantolactone was measured at ambient temperatures. The experiments were performed at 15.1 °C, 25.0 °C and 34.9 °C. The vapor pressure of RS-Pantolactone at 25 °C was calculated by interpolation from the vapor pressure curve.
The experimental parameters for the performance of the vapor pressure determination are summarized in Table 1. The results and the amount of nitrogen used to calculate the vapor pressure of the individual experiments are summarized in Table 2. The tabulated values represent rounded results that were obtained by calculation using the exact raw data. The vapor pressure of RS-Pantolactone was determined at 15.1 °C, 25.0 °C and 34.9 °C.To ensure saturation control, three different flow rates were used at each temperature. From Table 1 and Table 2 it can be clearly seen that higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.
The experimental results lead to the conclusion that the vapor pressure of the test item RS-Pantolactone is:
0.7 Pa at 15.1 °C
2.0 Pa at 25.0 °C
4.9 Pa at 34.9 °C
The vapor pressure at 25 °C was interpolated from the vapor pressure curve and was calculated to be 2.0 Pa.
The trapping efficiency of the test item RS-Pantolactone in the first cooling trap was very good. Between 99.6% and 100% of the test item was trapped in the first cooling trap. The trapping efficiency results are summarized in Table 3.
Figure 1 shows the vapor pressure curve of RS-Pantolactone. The interpolation data are given in Table 4. A typical chromatogram of a standard calibration solution is given in Figure 2. An example of a sample solution chromatogram from the experiment at 25 °C is shown in Figure 3. An example of the calibration data for test item standard is given in Figure 4 and Table 5. The r² fit was 0.9990 (optimum 1.0000). This reflects the suitability of the HPLC-system within the calibration range of 1.236 µg/mL to 98.88 µg/mL of the test item.
Table 1 Experimental Parameters used for the Gas Saturation Method of RS-Pantolactone
Column |
Temperature |
Flow Rate |
Collecting |
Volume V1 |
No. |
[°C] |
[mLn/min] |
[min] |
[mLn] |
1 |
15.1 |
41.85 |
4383 |
183428.55 |
2 |
52.90 |
231860.70 |
||
3 |
59.70 |
261665.10 |
||
1 |
25 |
42.30 |
1313 |
55539.90 |
2 |
53.00 |
69589.00 |
||
3 |
59.80 |
78517.40 |
||
1 |
34.9 |
41.70 |
131 |
5462.70 |
2 |
53.10 |
6956.10 |
||
3 |
60.05 |
7866.55 |
Table 2 Results of the Vapor Pressure Determination of RS-Pantolactone
Column No. |
Temp. |
Volume* |
Amount of test item in trap 1 |
Amount of test item in trap 2 |
Total amount of test item |
Vapor pressure |
Average vapor pressure |
|
[°C] |
[mL] |
[mg] |
[µg] |
[mg] |
[Pa] |
[Pa] |
1 |
15.1 |
193569 |
7.916 |
4.792 |
7.921 |
7.5 x 10-1 |
7.4 x 10-1 |
2 |
244678 |
9.404 |
5.296 |
9.409 |
7.1 x 10-1 |
||
3 |
276130 |
11.416 |
7.175 |
11.423 |
7.6 x 10-1 |
||
1 |
25.0 |
60623 |
6.097 |
7.129 |
6.104 |
1.9 x 100 |
2.0 x 100 |
2 |
75958 |
7.645 |
4.732 |
7.650 |
1.9 x 100 |
||
3 |
85704 |
9.218 |
5.044 |
9.223 |
2.0 x 100 |
||
1 |
34.9 |
6161 |
1.485 |
<2.472** |
<1.488 |
4.8 x 100 |
4.9 x 100 |
2 |
7845 |
1.992 |
8.503 |
2.001 |
5.0 x 100 |
||
3 |
8872 |
2.262 |
8.970 |
2.271 |
5.0 x 100 |
* Corrected volume at test temperature as calculated under Volume correction
** No test item could be detected at the relevant retention time
Table 3 Trapping Efficiency of RS-Pantolactone
Column |
Testing Temperature |
Amount of test item in |
Amount of test item in |
Total amount of test item |
Trapping efficiency |
No. |
[°C] |
[mg] |
[µg] |
[mg] |
[%] |
1 |
|
7.916 |
4.792 |
7.921 |
99.9 |
2 |
15.1 |
9.404 |
5.296 |
9.409 |
99.9 |
3 |
|
11.416 |
7.175 |
11.423 |
99.9 |
1 |
|
6.097 |
7.129 |
6.104 |
99.9 |
2 |
25.0 |
7.645 |
4.732 |
7.650 |
99.9 |
3 |
|
9.218 |
5.044 |
9.223 |
100 |
1 |
|
1.485 |
< 2.472 |
< 1.488 |
> 99.8 |
2 |
34.9 |
1.992 |
8.503 |
2.001 |
99.6 |
3 |
|
2.262 |
8.970 |
2.271 |
99.6 |
Applicant's summary and conclusion
- Conclusions:
- Calculation of the vapor pressure of RS-Pantolactone at 25 °C by interpolation based upon the simplified Clausius-Clapeyron equation resulted in a vapor pressure of 2.0 Pa at 25 °C.
- Executive summary:
During this study, the vapor pressure of the test item RS-Pantolactone has been determined using the gas saturation method. The vapor pressure of RS-Pantolactone was measured at test temperatures of 15.1 °C, 25.0 °C and 34.9 °C and was determined to be
0.7 Pa at 15.1 °C
2.0 Pa at 25.0 °C
4.9 Pa at 34.9 °C
The vapor pressure of RS-Pantolactone at 25 °C was interpolated from the vapor pressure curve and was calculated to be
2.0 Pa at 25 °C
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