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EC number: 205-743-6 | CAS number: 149-57-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Long-term effects for aquatic invertebrates are not expected.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC10
- Effect concentration:
- 19.9 mg/L
Additional information
A study on the toxicity of 2-ethylhexanoic acid (CAS 149 -57 -5) towards aquatic invertebrates was conducted as a non-GLP study according to OECD guideline 211 (Finnish Chemicals Oy., 1997; report no. E2702). Daphnia magna was used as a test organism. The test solutions were renewed 3 times per week. The analytical concentrations were monitored; however, the dilution water interfered with the analytical method for the monitoring of the test item concentrations. However, the test item is considered to be stable based on other available studies (e.g. NITE). After 21 days of exposure a NOEC of 25 mg/L and an EC50 of 75 mg/L were estimated based on the nominal concentrations.
As the study with ethylhexanoic acid is not performed under GLP and with regard to difficulties with the analytical method as well as the reproduction in the control, a study with sodium 2-ethylhexanoate (CAS 19766-89-3) is selected as key study.
Under supervision of the Japanese Ministry of the Environment, a semi-static reproduction test on Daphnia magna was conducted according to OECD 211 under GLP and published in 2002. The test concentrations were analytically verified and deviated less than 20% from the nominal concentrations. Moreover, the study was performed with the salt of the acid (Sodium 2-ethylhexanoate, CAS 19766-89-3) which resembles the acid after neutralization. By that, in this study, the toxicity of the test substance was not influenced by acidic pH effects.The test duration was 21 days. The NOEC for reproduction was determined to be 18 mg/L (NITE, 2002, report no.: A010465 -3).
The data of the original report were re-evaluated using ToxRat v3.3 in order to obtain an EC10, which is not originally reported (BASF SE, 2020). According to REACH Guidance document chapter R.10 Table R.10-1 (Overview of toxicity test endpoints and guidance on derivation of L(E)C50 and NOEC values) an EC10 for a long-term test which is obtained using an appropriate statistical method (usually regression analysis) will be used preferentially.
There has been a recommendation within OECD in 1996 to phase out the use of the NOEC, in particular as it can correspond to large and potentially biologically important magnitudes of effect. The advantage of regression method for the estimation of ECx is that information from the whole concentration-effect relationship is taken into account and that confidence intervals can be calculated. These methods result in an ECx, where x is a low effect percentile (e.g. 5-20%). It makes results from different experiments more comparable than NOECs. The recalculation fulfills the required validity criteria.
The 21 -d EC50 (reproduction) was 43.1 mg/L (95% CL: 34.8 - 53.5 mg/L; based on nominal concentrations, recalculated, BASF SE, 2020). The 21 -d EC10 (reproduction) was determined to be 19.9 mg/L (95% CL: 9.9 - 26.6 mg/L; based on nominal concentrations, recalculated, BASF SE, 2020).
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