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EC number: 201-842-3 | CAS number: 88-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature, reproduced from SIAR 6-tert-Butyl-m-cresol, 08.08.2002
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Sumitomo Chemical (1976)
- Year:
- 1 976
- Bibliographic source:
- cited: OECD SIDS Initial Assessment Report, Boston 20-25th Oct. 2002
Materials and methods
- Principles of method if other than guideline:
- 10 male/female mice per group received a dose of 500, 750, 1000, 1750, 2500 and 5000 mg/kg bw of 6-tert-butyl-m-cresol
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 6-tert-butyl-m-cresol
- EC Number:
- 201-842-3
- EC Name:
- 6-tert-butyl-m-cresol
- Cas Number:
- 88-60-8
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-tert-butyl-5-methylphenol
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: cotton oil
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- 500, 750, 1000, 1750, 2500, 5000 mg/kg
- No. of animals per sex per dose:
- 10/group
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 200 mg/kg bw
- Mortality:
- male rats: dose 500 mg/kg bw, mortality 0/10; dose 750 mg/kg bw, mortality 0/10; dose 1000 mg/kg bw, mortality 5/10; dose 1750 mg/kg bw, mortality 7/10; dose 2500 mg/kg bw, mortality 10/10; dose 5000 mg/kg bw, mortality 10/10
female rats: dose 500 mg/kg bw, mortality 0/10; dose 750 mg/kg bw, mortality 2/10; dose 1000 mg/kg bw, mortality 4/10; dose 1750 mg/kg bw, mortality 7/10; dose 2500 mg/kg bw, mortality 10/10; dose 5000 mg/kg bw, mortality 10/10 - Clinical signs:
- other: decrease of spontaneous activity, ataxia, hyperpnea, poor appetite, pilo-erection, edema in application site. Toxic signs were observed decrease of spontaneous activity and pilo-erection in 750 mg/kg or more, and ataxia, hyperpnea and poor appetite in 100
- Gross pathology:
- no remarkable change was found in macroscopic observation
- Other findings:
- no data
Any other information on results incl. tables
Cumulative Daily Mortality (Mouse Dermal)
Male
Dose(mg/kg) Cum.Mortal. Time of deat
500 0/10
750 0/10
1000 5/10 d1:5an
1750 7/10 d1:6an,
d2:1an
2500 10/10 d1:10an
5000 10/10 d1:10an
Female
Dose(mg/kg) Cum.Mortal. Time of deat
500 0/10
750 2/10 d1:2an
1000 4/10 d1:3an,
d6:1an
1750 7/10 d1:7an
2500 10/10 d1:10an
5000 10/10 d1:10an
Cum. Mortal.= Cumulative Mortality; No. of animals which died/ No. of animals used
an= animal, d= da
Applicant's summary and conclusion
- Executive summary:
method: 10 male/female mice per group received a dose of 500, 750, 1000, 1750, 2500 and 5000 mg/kg bw of 6-tert-butyl-m-cresol
result: LD50 = 1200 mg/kg bw (mouse, male + female)
reference: Sumitomo (1976)
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