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EC number: 213-928-8 | CAS number: 1067-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not conducted in line with standard test guidelines but in line with sound scientific principles, so the quality of the results from the study can be considered acceptable.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- Conducted in line with the methodology reported in Kverno (1954) and Kverno et al. (1965). Repellency and acute oral toxicity tests were performed on 933 chemicals on wild deer mice and house mice.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Dibutyltin di(acetate)
- EC Number:
- 213-928-8
- EC Name:
- Dibutyltin di(acetate)
- Cas Number:
- 1067-33-0
- Molecular formula:
- C12H24O4Sn
- IUPAC Name:
- dibutyltin di(acetate)
- Details on test material:
- The chemicals included in the tests were technical or analytical grade pesticides and other commercially available or experimental chemicals. They were purchased from various commercial sources or contributed by cooperating chemical companies.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: deer mouse and house mouse
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- -Source: Wild-trapped deer mice (Peromyscus maniculatus) and domestically bred house mice (Mus musculus)
-Method for testing procedures described in detail by Kverno (1954) and Kverno et al. (1965)
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: water, corn oil, or 1.0% carbopol
- Details on oral exposure:
- Deer mice were offered 25 white wheat seeds treated with 2% (wt/wt) of the candidate chemicals (dibutyltin diacetate) daily for 3 days, followed by 4 days of observation for gross and sub-acute effects. An alternal less-preferred food (laboratory rodent pellets) and water were available ad lib. Mortality and the number of wheat seed consumed daily were recorded. The total number of treated seeds consumed by all mice over the 3-day test period were subtracted from the total number available. The difference was converted into the percentage of seeds refused, and the value was designated as the FR (food reduction)
- Doses:
- Using a single animal per dose level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred.
- No. of animals per sex per dose:
- Approximate Lethal Dose (ALD) = 6 mice
LD50 = 2-4 per dosage level - Control animals:
- not specified
- Details on study design:
- Two acute oral toxicity tests were conducted on deer mice. The first, the ALD (Approximate Lethal Dose), represented a range-finding modification of the Deichman and LeBlanc (1943) method using approximately 6 animals and a graduated dosage scale. Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred. All chemicals were administered by gavage using water, corn oil, or 1.0% carbopol as carriers followed by 3-days of observations for mortality.
The second toxicity test (LD50) was conducted on a more limited basis in a similar manner, except that 2 to 4 animals were used per geometrically spaced dosage level. These tests generally required 6 to 20 animals per experiment. The final set of toxicity data was derived from the FR value, the known average weight of individual wheat seeds (50 mg) and the known average weight of each individual deer mouse (20 g). This calculated value, the LDfr represented the average amount of chemical, in mg/kg/day, that was ingested by each animal over the 3-day test period without killing more than 50% of the test animals. - Statistics:
- The statistical method used to estimate the acute oral LD50 was that of Thompson (1948) and Thompson and Weil (1952).
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: approximate lethal dose
- Effect level:
- 1 070 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- other: LDfr
- Effect level:
- 87.5 other: mg/kg/day
- Remarks on result:
- other: LDfr, represented the average amount of chemical. in mg/kg/day, that was ingested by each animal over the 3-day test period without killing more than 50% of the test animals
- Mortality:
- The LD50 represented the average amount of chemical, in mg/kg/day, that was ingested by each animal over the 3-day test period without killing more than 50% of the test animals.
- Clinical signs:
- other: Not described
- Gross pathology:
- Not described
- Other findings:
- The food reduction test, using 2% treated wheat seeds, resulted in 93% seeds refused by deer mice. The food reduction test, using 2% treated Douglas Fir seeds, resulted in 13% seeds refused by deer mice. 100% of house mice refused to eat more than 50% of the 2% treated wheat seeds.
Any other information on results incl. tables
The Approximate Lethal Dose for the Deer Mouse was determined to be at 1070 mg/kg; The LDfr* was determined to be 87.5 mg/kg/day.
* LDfr, represented the average amount of chemical. in mg/kg/day, that was ingested by each animal over the 3-day test period without killing more than 50% of the test animals.
Applicant's summary and conclusion
- Interpretation of results:
- other: Poor quality of study makes interpretation of results not possible
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- An approximate lethal dose of dibutyltin diacetate in deer mice was determined to be 1070 mg/kg. A second toxicity test determined the LD50 of dibutyltin diacetate of >87.5 mg/kg/day.
- Executive summary:
These authors reported an ALD (approximate lethal dose) for dibutyltin di(acetate) of 1070 mg/kg in wild caught deer mice. The ALD represented a range-finding modification of the Deichman and LeBlanc (1943) method using approximately 6 animals and a graduated dosage scale. Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred. All chemicals were administered by gavage using water, corn oil, or 1.0% carbopol as carriers followed by 3-days of observations for mortality. The authors also reported a second toxicity test (LD50) conducted on a more limited basis in a similar manner, except that 2 to 4 animals were used per geometrically spaced dosage level. The statistical method used to estimate the acute oral LD50 was that of Thompson (1948) and Thompson and Weil (1952). These tests generally require from 6 to 20 animals per experiment. The LD50 for dibutyltin (di)acetate was determined to be >87.5 mg/kg/day.
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