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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Authoritative secondary source

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Approximately 100 pregnant female Long Evan rats received a diet containing 4% lead carbonate post partum. Offspring were sacrificed up to 71 days of age, having received 4% lead carbonate in the diet after cessation of suckling.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trilead bis(carbonate) dihydroxide
EC Number:
215-290-6
EC Name:
Trilead bis(carbonate) dihydroxide
Cas Number:
1319-46-6
Molecular formula:
C2H2O8Pb3
IUPAC Name:
tris(λ²-lead(2+)) dihydroxide dicarbonate

Test animals

Species:
rat
Strain:
Long-Evans

Administration / exposure

Route of administration:
oral: feed
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
71 d
Frequency of treatment:
daily
Duration of test:
71 d
Doses / concentrations
Remarks:
Doses / Concentrations:
4%
Basis:
nominal in diet
No. of animals per sex per dose:
100 females post partum
Offsprings (number not reported)
Control animals:
not specified

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:
Maternal toxic effects:not examined

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:yes

Details on embryotoxic / teratogenic effects:
Retardation in growth
At 23–29 days of age approximately 90% of the offspring developed paraplegia for up to 2 weeks, with about 85%–90% of these animals dying
Histopathological changes were seen in the cerebellum indicative of encephalo-myelopathy

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The substance was found to be neurotoxic to the offsprings at the concentration tested