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Diss Factsheets
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EC number: 500-245-8 | CAS number: 70750-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to OECD Guideline and subject to GLP audit
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- Limit test at 1 dose level
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Terpenes and terpenoids, turpentine oil, alpha-pinene fraction oligomers
- IUPAC Name:
- Terpenes and terpenoids, turpentine oil, alpha-pinene fraction oligomers
- Reference substance name:
- Terpenes and terpenoids, turpentine-oil, α-pinene fraction, oligomers
- EC Number:
- 500-245-8
- EC Name:
- Terpenes and terpenoids, turpentine-oil, α-pinene fraction, oligomers
- Cas Number:
- 70750-57-1
- Molecular formula:
- C10H16 - C50H80
- IUPAC Name:
- Terpenes and terpenoids, turpentine-oil, α-pinene fraction, oligomers. “2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, oligomers, consisting of mainly of dimers and trimers formed from the catalytic partial homo-polymerisation of 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene (also known as alpha-pinene)”,
- Test material form:
- other: clear viscous honey-like liquid
- Details on test material:
- - Name of test material (as cited in study report): Zonarez A-25
- Physical state: Clear viscous honey-like liquid
- Analytical purity: Not reported
- Lot/batch No.: AIA804
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Wilmington, Massachusetts
- Age at study initiation: Not reported
- Weight at study initiation: Male: 225-275 grams (before fasting)
- Fasting period before study: 18 hrs
- Housing: Individual stainless steel1/2 wire mesh cages.
- Sanitization: Waste material was removed daily. Cages and feeders were sanitized every two weeks
- Diet (e.g. ad libitum): Purina Certified Rodent Meal #5002, ad libitum, checked daily.
- Food analysis: No contaminants were detected.
- Water (e.g. ad libitum): Fresh tap water, fit for human consumption, ad libitum, using an automatic watering system supplied by Edstrom Industries Inc.
- Water analysis: Conducted by Pennsylvania Gas and Water Company
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 30-70%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12 hrs light, 12 hrs dark
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- VEHICLE
- Information not reported
MAXIMUM DOSE VOLUME APPLIED:
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Potential route for human exposure - Doses:
- Dose administration: 5000 mg/kg
Volume administration: 5 ml/kg - No. of animals per sex per dose:
- 5 females and 5 males
- Details on study design:
- - Frequency and duration administration: Once
- Length of the study: 15 days
- Frequency of observations and weighing: Weight and death body weights were recorded on Days -1, 1, 2, 3, 4, 7, 11.
- Necropsy of survivors performed: yes
- Other examinations performed: Twice daily rats were observed for clinical effects, CNS effects and mortality. - Statistics:
- Not reported
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study
- Clinical signs:
- other: 5 hrs after dosing: piloerection was observed in 7/10 rats At Day 2: Diarrhea and piloerection, and decreased body were observed in 2 different rats. At Day 3: Decreased body tone was observed in 1 rat.
- Gross pathology:
- No visible lesions
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The estimated acute oral LD50 in rats for Terpenes and terpenoids, turpentine oil, alpha-pinene fraction oligomers was determined to be greater than 5000 mg/kg.
- Executive summary:
The study investigated the Acute oral toxicity of Terpenes and terpenoids, turpentine oil, alpha-pinene fraction oligomers on female and male Sprague-Dawley rat. A single dose of 5000 mg/kg was administered orally by gavage and animals were observed for 14 days. No mortality occurred during the study and no visible lesions were recorded at necroscopic analysis. Piloerection and diarrhea were observed in 7 rats after dosing. After 2 days diarrhea and piloerection, and decreased body were observed in 2 different rats, while after 3 days decreased body tone was observed in 1 rat.
In conclusion, the acute oral toxicity in rats was determined to be greater than 5000 mg/kg.
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