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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
non skin irritant
eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The eye and skin irritation of the substance are evaluated by considering data on Similar Substances in a weight of evidence approach. Justification for Read Across is given in Section 13 of IUCLID.
Skin irritation
The skin irritation on similar substances are evaluated in in vitro systems and also in an in vivo study.
The tissue viability determined in the in vitro studies was above the threshold for classification of the substance as a skin irritant or skin corrosive.
The skin irritation/corrosion potential of the similar substance was evaluated also in vivo. The substance was applied on the shaved skin of six Newzeland albino rabbit in an occlusive coverage. Based on the scores of erythema and edema, the test material does not present any signs of irritation.
The test substance is therefore not considered as a skin irritant.
Eye irritation
The eye irritation of the substances was evaluated in in vivo studies and also in an in vitro / ex vivo studies.
The in vivo study (1984) identifies the test material as an eye irritant based on the scores of cornea, conjuctivae redness and conjuctivae chemosis. The other two in vivo studies could not be used for classification assessment since only two animals were tested; no eye irritation was observed in cornea and iris, slight irritation was observed in conuctivae (redness and chemosis).
The ocular irritancy potential of the test material was assessed after application onto the cornea of an enucleated rabbit eye in three other studies. The %corneal swelling suggested that the test materials are unlikely to have the potential to cause severe ocular irritancy in vivo.
Following a conservative approach and considering the results of the in vivo study (1984) the substance is considered as an eye irritant.
Justification for classification or non-classification
Based on the available studies the substance should not be classified for skin irritation but should be classified as an Eye Irritant (Cat.2) -H319 according to the CLP Regulation (EC) No. 1272/2008.
Furthermore, a component of the UVCB substance classified as Skin Corr. 1B (H314) is in a percentage that does not allow the classification of the UVCB substance in the same category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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