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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- L-Tyrosine, N-acetyl-3,5-dinitro-, etyhl ester
- Cas Number:
- 29358-99-4
- Molecular formula:
- C13H15N3O8
- IUPAC Name:
- L-Tyrosine, N-acetyl-3,5-dinitro-, etyhl ester
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.875 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 4.1 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20.02 °C
- pH:
- >= 5 - <= 6
Applicant's summary and conclusion
- Conclusions:
- The solubility of L-Tyrosine, N-acetyl-3,5-dinitro-, ethyl ester in water was determined from the measured concentrations of test item in the filtered test item solutions.
Equilibration time can be considered as approx. 1 day, as the values which were measured on the following consecutive days did not give significantly different values.
All replicates showed good correspondence. The mean test item concentration of the sam-ples (flask 2 - 6), which were used for the calculation of water solubility (at plateau) was 0.875 ± 0.028 g/L (mean ± standard deviation), corresponding to a relative standard devia-tion of 3.2 %.
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
- Executive summary:
The solubility of the test item L-Tyrosine, N-acetyl-3,5-dinitro-, ethyl ester in water was determined by measurement of test item concentration in the filtrated test solutions using HPLC method.
The estimated solubility in water was 822 mg/L for nominal concentration 1 g/L test item in water, tested in the validation of 19120203G (VB19120203G926).
Therefore, the preliminary study described in the guideline was not performed. According to the guideline, the flask method was used for the determination of the solubility of the test item in water.
In the main test, one loading rate of the test item with 4.1 g/L (nominal) was chosen. Three flasks 1A - C were sampled during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h), Blanc and 2 – 6) were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature. Then, flasks 1A, 1B and 2 were taken from the shaker and tempered to 20.0 ± 0.5 °C. Samples were taken after homogenising and filtered with 0.45 µm PTFE filters. The clear samples were analysed after sample preparation via HPLC.
After the analysis of the sample of day 3, the plateau was considered as reached, because of a difference of less than 15 % in the concentrations on days 2 and 3 and no upward tendency.
For organizational reasons, the flasks 2 - 6 were sampled on the following day (day 4).
No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles are present.
At the plateau, the concentration of L-Tyrosine, N-acetyl-3,5-dinitro-, ethyl ester in water had reached
0.875 ± 0.028 g/L at 20.2 ± 0.1 °C
= 0.875 ± 0.028 kg/m3 (SI units)
(mean value ± standard deviation of five individual vessels)
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