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Diss Factsheets
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EC number: 944-574-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Minimal absorption via oral, dermal or inhalation routes of exposure has been predicted based on the experimental data, physico-chemical properties of the substance and expected use patterns., if absorbed, the test item could undergo primary Phase I reaction followed by subsequent conjugation reactions (Phase II). The conjugated metabolites are expected to be excreted via the urine or via the faeces. The substance will not bioaccumulate.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Physicochemical properties:
The test item is a UVCB substance with an average molecular weight of 515 g/moL. The material is a waxy solid (melting point 26 to 42 °C) with a water solubility of 0.025mg/L at 20°C. Octanol/water partition coefficient was determined to be Log Kow > 10.0 for the UVCB substance as a whole (which is > 4, the bioaccumulation limit), and the vapour pressure is low (0.323 Pa at 25 °C). The substance is not expected to be surface active.
Absorption
Oral route
Passive diffusion (transcellular) and passage through the aqueous pores (para-cellular) are the primary absorption mechanisms of molecules from the gastro-intestinal (GI) tract. Key physicochemical properties that determines the mechanism of absorptions are molecular weight (MW), Log Kow and aqueous solubility. Log Kow values in the range of 0 - 3 and a MW less than 500 g/moL favours paracelluar transport. Molecules that pass through transcellular route are small (molecular weight up to around 200 g/moL) water-soluble molecules. Based on this, the test item is expected to have a low absorption potential from the GI tract because of the large molecule size (MW of 515 g/moL), high lipophilicity (Log Kow of >10) and low water solubility (0.025mg/L).
Inhalation route
Volatility, aqueous solubility and Log Kow values determine the inhalation uptake. The substance is a low melting point solid at room conditions and has a high boiling point (300°C) suggesting that the potential for exposure through inhalation route is less likely at standard conditions. Low melting point solid having low water solubility, it will not readily dissolve into the mucus lining the respiratory tract and because of the high Log Kow value it would not be absorbed directly across the respiratory tract epithelium.
Dermal route
The skin absorption rate of molecules with a Log Kow value in the range of < -1 or > 4 and the molecular weight of > 500 g/moL is considered low. The test item is expected to be poorly absorbed through the skin considering its poor water solubility and the relatively high Log Kow.
Distribution
The extent of distribution of molecules is affected by molecular weight, lipid solubility, pKa, and plasma protein binding (PPB). Molecules that are lipophilic at pH 7.4 and high plasma protein binding are likely to have high volume of distribution (Vd). Physicochemical properties that influence PPB include lipophilicity and pKa. In general, chemicals with high lipophilicity and/or ones with acidic character will have a greater degree of PPB, than more hydrophilic or basic compounds. Once absorbed, the substance is expected to have a high volume of distribution due to its high Log Kow values. The high Log Kow value of the test item can result in initially partitioning preferentially into highly vascularized lipid rich areas.
Metabolism and excretion
The substance will undergo primary Phase I reaction followed by subsequent conjugation reactions (Phase II). The metabolites could be excreted via the urine or via the feces.
Conclusions
A qualitative judgement on the toxicokinetic behavior of the substance was performed based on the physico-chemical characteristics. The test item is expected to be poorly absorbed via the oral, dermal and inhalation routes. The substance is expected to be widely distributed through the body, if absorbed in to systemic circulation. The test item might undergo primary Phase I reaction followed by subsequent conjugation reactions (Phase II). The conjugated metabolites are expected to be excreted via the urine or via the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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