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EC number: 813-266-5 | CAS number: 45101-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
6-chlorohexyl methacrylate is suspected to be skin sensitiser based on its similarity with short chain alkyl methacrylates.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
No data is available for skin sensitisation of 6-chlorohexyl methacrylate (6-CHMA).
Some concern for skin sensitisation of 6-CHMA is expected based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). As reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004), these chemicals are weak sensitisers although there are equivocal results regarding their skin sensitisation.
In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2-ethylhexyl methacrylate (2 -EHMA) CAS 688-84-6 two studies both with high reliability but with different results are reported:
1) 2-EHMA was not skin sensitiser in a study conducted in 1999 according to OECD 406 Guinea Pig Maximisation test (Result: 0/20 animals tested) (Ref. Allen DJ, 1999, EMPICRYL 6068: Magnusson & Kligman Maximisation Study in the Guinea Pig. Safepharm Labs. Ltd., UK Unpublished report SPL project no. 071/634 on behalf of Albright and Wilson)
2) 2-EHMA was skin sensitiser in as study conducted in 1981 according to OECD 406 Guinea Pig Maximisation test (Result: 3/10 animals tested) (Ref. Poole, 1981, Methacrylate de 2-ethyl hexyle (MAE2H); Test for contact sensitisation potential in the Guinea Pig (maximisation test). ICLS Labs. Ltd., Kimpton, unpublished report no. CL81:51:2141, study on behalf of Norsolor / Atofina)
Based on precautionary principle and based on some human studies on skin sensitisation regarding short chain methyl methacrylates reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004), the classification H317 (Skin Sens. cat.1) is suggested for 6-chlorohexyl methacrylate according to the CLP Regulation (EC n. 1272/2008).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data is available for respiratory sensitisation of 6-chlorohexyl methacrylate (6-CHMA).
No concern for respiratory sensitisation of 6-CHMA is expected based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). As reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) no cases of human studies of respiratory allergy due to the members of this category have been reported in literature.
Justification for classification or non-classification
No data is available for skin and respiratory sensitisation of 6-chlorohexyl methacrylate (6-CHMA) but some concern for skin sensitisation of 6-CHMA is expected based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
Based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for similar compounds and based on the classification included in annex VI of the CLP regulation for some of them (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier) , the classification H317 (Skin Sens. cat.1) is suggested for 6-chlorohexyl methacrylate (6-CHMA) according to the CLP Regulation (EC n. 1272/2008).
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