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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Not readily biodegradable: 52% in 28 days (OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
The ready biodegradability of Amides, C18, branched and linear was
investigated in a GLP study following OECD Guideline 301B (Roulstone,
2015). The inoculum, predominantly domestic non-adapted sewage, was
exposed to a substance concentration of 10 mg carbon/L for 28 days. The
biodegradation rate was determined by measuring the CO2 produced by
degradation. A degradation rate of 52% was determined at test
termination. The toxicity control showed no inhibitory effect of the
test substance. A degradation rate of 63% was determined after 14 days
and 67% biodegradation after 28 days of incubation. Thus, the test item
is considered not inhibitory to activated sludge microorganisms. Amides,
C18, branched and linear is an UVCB substance consisting mainly of two
components with different degradation rates. QSAR calculations give
opposite results for the substance components (BIOWIN v4.10, VEGA
1.1.0). Both estimation programmes predict ready biodegradability for
the C18 linear component, whereas the prediction for the C18 iso
component is not readily biodegradable. The biodegradation rate of the
whole substance might thus be related to a delayed degradation of the
C18 iso component. Though the results demonstrated no ready
biodegradability a high persistency of the substance in the environment
is not expected. This assumption is supported by data on the structural
analogue substance erucamide (CAS 112-84-5). The substance was degraded
by 64% after 28 days in a study, following OECD 301B, (Mead, 2000).
Though the substance failed the 10-days window criterion it was
considered readily biodegradable. The available data illustrate that
testing the ready biodegradability of fatty amides produces varying
results. The difficulties in testing the biodegradability result most
likely from the low water solubility of the substances. Similar findings
are reported in a hazard characterisation for fatty nitrogen derived
amides by the U.S. EPA (2010). The report comes to the conclusions that
fatty amides possess low persistence in the environment.
Thus, based on the experimental results Amides, C18, branched and linear
has to be considered potentially persistent. However, a low potential to
persist in the environment is anticipated for the substance.
A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
References:
US EPA, 2010: Screening-level hazard characterisation. Fatty Nitrogen Derived (FND) Amides Category
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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