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Diss Factsheets
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EC number: 938-677-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The key study for this endpoint (Clarke, 2010) was conducted under GLP conditions and to the OECD guideline 209 using ammonium zirconium carbonate as test material. The study reported a 3 hour NOEC of >1000 mg/l for sewage microorganisms collected from a predominantly domestic sewage treatment plant. The study was conducted at test concentrations of 10, 32, 100, 320 and 1000 mg/l.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
The toxicity of the test material to microorganisms is being addressed using a key study (Clarke, 2010) on a surrogate substance, using the read across argument based on its common ionic compounds. Toxicity to microorganisms was investigated in a GLP compliant study performed in accordance with the standardised guidelines using the surrogate substance ammonium zirconium carbonate. The study was performed to a good standard with a sufficient level of reporting to be assigned a reliability score of 2 according to the principles for assessing data quality set out in Klimisch (1997).
Information provided by the Sponsor indicated that at the pH and concentration used in this study the test item was likely to have become unstable. It is considered likely that the addition of the test item to water resulted in the rapid decomposition of the substance to form zirconium hydroxide, together with accompanying release of carbonate and ammonium ions to the solution. All concentrations have thus been given as nominal values.
The sewage sludge micro-organisms were exposed to the test material for 3 hours at the following concentrations: 10, 32, 100, 320 and 1000 mg/l. The sample was maintained in continuous aeration in the laboratory under constant conditions. After the 3 hour exposure time, samples were removed and placed in a BOD bottle and the rate of respiration was measured over the linear portion of the oxygen consumption trace. The inhibitory effect as a result of exposure was also calculated as percentage inhibition, this was plotted against concentration for the reference item only and a line fitted using the Xlfit software package. The EC₁₅, EC₂₀, EC₅₀ and EC₈₀ values determined from the equation for the fitted line.
The effect of the test item on the respiration of activated sewage sludge micro-organisms gave a 3-Hour EC₅₀ of greater than 1000 mg/l. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/l.
Key value for chemical safety assessment
NOEC: 1000 mg/l
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