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Diss Factsheets
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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to IUCLID section 13 for Read Across Justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 54 890 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 53200-56630 mg/L
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to IUCLID section 13 for Read Across Justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 min
- Dose descriptor:
- EC50
- Effect conc.:
- 71 700 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of movement
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Laboratory test performed according to standard procedures, but poorly documented and without information on important test parameters, like temperature. Tested species is not standard organism and is also not included in any of the National and international standard methods / Guidelines listed in the EChA Guidance on Information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance (November 2012).
- Qualifier:
- according to guideline
- Guideline:
- other: APHA (1989) Standard methods for the examination of water and wastewater, 18th ed
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Branchiura sowerbyi
- Details on test organisms:
- -Mean length: 20 +/- 7 mm
-Mean weight: 2.05 +/- 1.25 mg - Study type:
- laboratory study
- Test type:
- semi-static
- Water media type:
- freshwater
- Duration:
- 96 h
- Exposure phase:
- total exposure duration
- Hardness:
- 109 +/- 7.2 mg/L as CaCO3
- Test temperature:
- not reported
- pH:
- 7.34 +/- 0.12
- Dissolved oxygen:
- 6.45 +/- 0.56 mg/L
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 54 890 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 53200 - 56630
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a 96-hour semi-static freshwater test with Branchiura sowerbyi according to an national method (APHA, 1989; Standard methods for the examination of water and wastewater) ten worms (four replicates) were used for each concentration of methanol. The 96 h LC50 was determined to be 54890 mg/L (nominal).
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- New short term toxicity test for Tubifex, verified by statistical comparison with other toxicity data.
- Principles of method if other than guideline:
- New short term (3 min) test for Tubifex
- GLP compliance:
- not specified
- Test organisms (species):
- Tubifex tubifex
- Study type:
- laboratory study
- Test type:
- static
- Water media type:
- freshwater
- Duration:
- 3 min
- Exposure phase:
- total exposure duration
- Test temperature:
- room temperature
- Reference substance (positive control):
- yes
- Remarks:
- manganese chloride CAS: 20603-88-7
- Key result
- Duration:
- 3 min
- Dose descriptor:
- EC50
- Effect conc.:
- 71 700 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of movement
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a freshwater short-term toxicity test with Tubifex tubifex under static conditions a 3-minute EC50 of 7700 mg/L (based on inhibition of movement) was derived. This result was verified by statistical comparison with other toxicity data.
Referenceopen allclose all
Description of key information
In compliance with REACH Annex X this endpoint was waived because the chemical safety assessment of the registration substance did not reveal the need to investigate further effects to sediment organisms.
Key value for chemical safety assessment
Additional information
According to column 2 in Annex X to Regulation (EC) 1907/2006 (REACH) testing of long-term toxicity to sediment organisms shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further effects on sediment organisms. The registration substance is neither classified for environmental hazards according to Regulation (EC) 1272/2008 (CLP), nor is it identified as PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. This conclusion is supported by assessments for the structural analogues Methanol (CAS 67-56-1) and Methyl acetate (CAS 79-20-9) provided in its public ECHA REACH dossiers demonstrating that long-term toxicity to sediment organisms is not to be expected. Therefore, generating additional data is scientifically not justified.
However, data on the toxicity of the read across source substance Methanol is publicly available.
In a 96-hour semi-static freshwater test with Branchiura sowerbyi according to an national method (APHA, 1989; Standard methods for the examination of water and wastewater) ten worms in four replicates were used for each concentration of methanol. The 96 h LC50 was found to be 54890 mg/L in nominal (Kaviraj et al., 2004).
In a freshwater short-term toxicity test with Tubifex tubifex under static conditions a 3-minute EC50 of 7700 mg/L (based on inhibition of movement) was derived. This result was verified by statistical comparison with other toxicity data (Tichy, 2007).
Conclusion
Available information from public literature on effects of methanol on sediment organisms indicates very low acute toxicity. Moreover, since the substance exhibits a low log Pow and low log Koc exposure of sediment organisms is unlikely and testing towards sediment dwelling organisms not necessary. The equilibrium partitioning method can be used for assessing the hazard of sediment organisms. The expected low toxicity towards sediment organisms is underlined by the available studies of Tichy (2007) and Kaviraj (2004) where an EC50 of 71700 mg/L for Tubifex tubifex and a LC50 of 54890 mg/L were observed. Furthermore, the equilibrium partitioning method can be used for assessing the hazard of sediment organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.