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EC number: 482-140-6 | CAS number: 13641-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- from MHRA (UK GLP Monitoring authority)
Test material
- Reference substance name:
- -
- EC Number:
- 482-140-6
- EC Name:
- -
- Cas Number:
- 13641-96-8
- Molecular formula:
- Hill formula: C6 H7 N O3 CAS formula: C6 H7 N O3
- IUPAC Name:
- 2-isocyanatoethyl prop-2-enoate
Constituent 1
Study design
- Buffers:
- Preparation of buffer solutions
pH 4.0 : Potassium dihydrogen orthophosphate (3.00 g) and disodium hydrogen
orthophosphate dodecahydrate (6.40 g) were dissolved in purified water (950 ml)
and the pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid. The volume was
then adjusted to 1000 ml with purified water.
pH 7.0 : Potassium dihydrogen orthophosphate (6.80 g) was dissolved in purified water
(950 ml), 1M sodium hydroxide (30 ml) was added and the pH was adjusted to
7.0 ± 0.05 with 1M hydrochloric acid. The volume was then adjusted to 1000 ml
with purified water.
pH 9.0 : Disodium tetraborate decahydrate (16.6 g) and potassium dihydrogen
orthophosphate (1.80 g) were dissolved in purified water (950 ml) and the pH was
adjusted to 9.0 ± 0.05 with 1M hydrochloric acid.. The volume was then adjusted
to 1000 ml with purified water. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Wheaton vials
GC CONDITIONS
Instrument: Hewlett Packard 5890 Gas Chromatograph
Column: HP-1 (25 m x 0.32 mm internal diameter x 0.52 μm film thickness)
Carrier gas: Helium
Flow: 1.6 ml/min
Oven temperature
Initial: 50°C
Ramp: 10°C/min to 150°C, then 50°C/min to 300°C
Final: 300°C (5 min)
Injection temperature: 250°C
Injection volume: 1 Hl (splitless)
Detector: FID
Detector gas flows
Air: Approximately 300 ml/min
Hydrogen: Approximately 30 ml/min
Auxiliary (helium) 29 ml/min
Detector temperature: 300°C
Retention time: Approximately 6.5 minutes
TEST MEDIUM
- Volume used/treatment
- Kind and purity of water:
- Preparation of test medium:
- Identity and concentration of co-solvent:
OTHER TEST CONDITIONS
- Adjustment of pH: yes
- Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Preliminary study:
- 50% hydrolysis had occurred after 10 minutes, indicating a half-life of significantly less than 1 day under environmental conditions (25°C). The test substance was determined to be hydrolytically unstable under acidic, neutral and basic conditions.
- Transformation products:
- not specified
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- < 10 min
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- < 10 min
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- < 10 min
Any other information on results incl. tables
pH |
Ct (mg/l) |
||||
t0min |
t10min |
|
|||
Measured |
Mean |
Measured |
Mean |
|
|
4 |
76, 79 |
78 |
0.2, 0.1 |
0.2 |
|
7 |
71, 63 |
67 |
0.3, 0.3 |
0.3 |
|
9 |
48, 54 |
51 |
1.4, 1.4 |
1.4 |
|
Where Ct is the concentration of AOI in solution at time tmin (in minutes) |
pH change during preliminary hydrolysis test
Nominal pH | Initial buffer pH | Buffer pH after addition of test substance |
4 | 3.9 | 4.2 |
7 | 7.0 | 7.0 |
9 | 9.0 | 9.0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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