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EC number: 428-310-5 | CAS number: 225789-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02.2003 - 03.2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Version / remarks:
- Rivised July 17, 1992
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- TOC removal
- Reference substance:
- aniline
- Preliminary study:
- no primary study
- Key result
- Parameter:
- % degradation (TOC removal)
- Value:
- 1
- Sampling time:
- 28 d
- Results with reference substance:
- The Degradation of Aniline was 79 % after 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test item rapidly hydrolyzed into aluminium and diethylphosphinic acid under the present test conditions. Aluminium and diethylphoshinic acid were not biodegraded by microorganisms and remained.
- Executive summary:
The test item rapidly hydrolyzed into aluminium and diethylphosphinic acid under the present test conditions. Aluminium and diethylphoshinic acid were not biodegraded by microorganisms and remained.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 40 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral salts medium acc. to OECD 301F
-Additional substrate: No
- Test temperature: 20,0 - 21.0 °C
- pH:
pH-Values in the Test Vessels at Test Start and Test End
pH-Value
Start End
Inoculum Control 7.72 1) 7.78
2) 7.76
Functional Control 7.72 1) 7.94
2) 7.20
Test Item 7.64 1) 7.62
2) 7.62
- pH adjusted: no
-dispersion treatment: continous stirring
- continous darkness: yes
TEST SYSTEM
- Culturing apparatus: Incubator
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: Closed bottles with a rubber sleeve with soda lime
- Measuring equipment: The oxygen consumption was determined in the incubation vessels by the OxiTop measuring system at 360 measuring points during the 28 d incubation period.
- Test performed in closed vessels due to significant volatility of test substance: - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- no preliminary study
- Test performance:
- Based on the calculated theoretical oxygen demand, the test concentration of 40 mg/L corresponding to an oxygen demand of 65.6mgO2/L in the vessel was selected.
The test solutions were prepared in measuring flasks and given into brown glass bottles as incubation vessels:
• 2 incubation vessels for the test item (P1, P2)
• 1 incubation vessels for the functional control (R1)
• 1 incubation vessel for toxicity control (T1)
• 2 incubation vessels for the inoculum control (C1, C2)
Separate replicates of test item and toxicity control were prepared for measurement of the pH-value at test start:
• 1 incubation vessels for the test item (P1)
• 1 incubation vessel for for toxicity control (T1)
•
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
- Details on results:
- Both test item replicates did not reach the 10% level (beginning of biodegradation) until day 28. The mean biodegradation after 28 days was 1%
- Results with reference substance:
- The pass level of a biodegradation >60 % was reached after 2 days. The validity criterion that the degradation should be > 60 % by day 14 was fulfilled. In the toxicity control the biodegradation achieved 46% after 14 days. After 28 days the biodegradation came to 47%. The validity criterion that the test item should not inhibit the biodegradation of the reference item was fulfilled.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item must be regarded as not readily biodegradable in the 10-d-window and after 28 days.
- Executive summary:
The ready biodegradability of the test item was determined with a non adapted activated sludge in the Manometric Respirometry test for a period of 28 days. The test item concentration selected as appropriate was 40 mg/L, corresponding to a ThOD of 65.6 mg O2/L per test vessel. The oxygen was depleted by respiration of bacteria and the degradation was followed by measuring the oxygen concentration. The biodegradation is therefore expresses as the percentage BOD and was calculated for each study day.
The mean oxygen depletion in the inoculum control was 9.9 mg O2/L on day 28. Both test item replicates did not reach the 10 % level until day 28. The mean biodegradation after 28 days was 1 %.
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 C (Inherent Biodegradability: Modified MITI Test (II))
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Exolit OP 1230 - Molecular formula: C12H30O6P3Al - Molecular weight: 390.3 g/mol - Physical state: Solid - Analytical purity: 98.7 % - Purity test date: 2008-03-04 - Lot/batch No.: DEH2005977 - Expiration date of the lot/batch: 2012-02-22 - Storage condition of test material: Room temperature protected from moisture and light
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): municipal sewage plant, Hildesheim and Sarstedt; composting plant, Hildesheim; lake, river, Sarstedt;
the inoculum was stirred and aerated continously. It was fed every working day. The inoculum was allowed to settle and one third of the supernatant was decanted and filled up with nutrient solution according to the guideline. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 50 mg/L
- Based on:
- ThOD/L
- Parameter followed for biodegradation estimation:
- other: Biological Oxygen Demand
- Details on study design:
- according to guideline
- Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 6
- St. dev.:
- 5.4
- Sampling time:
- 7 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 6
- St. dev.:
- 5.4
- Sampling time:
- 14 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 8
- St. dev.:
- 5.4
- Sampling time:
- 21 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 7
- St. dev.:
- 5.4
- Sampling time:
- 28 d
- Results with reference substance:
- The pass level of 65 % was reached by the first replicate after 5 days and by the second replicate after 3 days; the mean biodegradation on day 28 was 79%;
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- The test item must be regarded as not inherent biodegradable after 28 days
- Executive summary:
- The inherent biodegradability and the primary degradation of the test itemExolit OP 1230 (batchnumber: DEH2005977) were determined in the ModifiedMITI Test (II) with a non adapted activatedinoculum for a period of 28 days. The study was conducted from 2008-12-17 to 2009-01-14according to OECD guideline 302 C atDR.U.NOACK-LABORATORIEN, D-31157 Sarstedt. The test itemconcentration selected as appropriate was 50mg/L, corresponding to a ThOD of 82.0 mg O2/L pertest vessel. The oxygen was depleted by the respiration of bacteria andthe degradation was followedby measuring the oxygen concentration. The biodegradation rate is therefore expressed as thepercentage BOD and was calculated for each study day.The mean oxygen depletion in the inoculum control was 0.0 mg O2/L on day 28.In order to check the activity ofthe test system sodium benzoate was used as functional control. Thepass level of 65 % was reached by the 1streplicate after 5 days and by the 2ndreplicate after 3 days.The mean biodegradation after 28 days was 79 %.It can be assumed, that the test item did not cause inhibitory effects on bacteria. For details seereport "Exolit OP 1230Ready Biodegradability, Manometric RespirometryTest" (ARE12309/080317CP), S. Fiebig, DR.U.NOACK-LABORATORIEN.The inherent biodegradation rate of all three test item replicates remained 10 % (beginning ofbiodegradation) during 28 days. A maximum of 9 % was reached by the 1sttest item replicate on day19.The primary biodegradation/elimination was measuredby LC-MS/MS analysis at test start and testend. No primary biodegradation/elimination was determined at test end (Table 2).No elimination / abiotic degradation ofthe test item occurred in the blank.The validity criteria of the guideline are fulfilled.
Referenceopen allclose all
Description of key information
Three biodegradation tests are available.
One test regarding OECD Guideline 301 F shows only 1 % degradation after 28 days. In a second test regarding OECD guideline 301 C the same results was found (1 % after 28 days). In the third test regarding OECD Guideline 302 C the inherent biodegradability of the test item was investigated. After 28 days 7 % degradation was found.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
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