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EC number: 402-770-7 | CAS number: 92585-24-5 PAMPLEFLEUR
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames test
An Ames test was performed according to OECD TG 471, using S. typhimurium strains TA 1535, TA 1537, TA 98 and TA 100 as well as E.coli strains WP2, up to 5000 ug/pl. No mutagenicity was observed.
Mouse Micronucleus study:
An in vivo mouse micronucleus test was performed according to OECD TG 474 up to 871 mg/kg bw. Mice treated with Pamplefleur showed no significant increase in the frequency of micronucleated polychromatic erythrocytes. There was no siqnificant change in the ratio of polychromatic to normochromatic erythrocytes after treatment of the animals with Pamplefleur. The substance is not considered genotoxic in this test.
Justification for selection of genetic toxicity endpoint
One AMES study was conducted with Pamplefleur according to OECD TG 471 guidelines, including GLP and with a reliability 1 and no mutagenicty was observed under the conditions of this test. There was also an OECD TG 474 in vivo mouse micronucleus study conducted under GLP and with a reliability 1, which showed no genotoxicity.
Short description of key information:
AMES study:
It is concluded that Pamplefleur shows no evidence of mutagenic activity when tested in this bacterial system.
Mouse Micronucleus:
From the results obtained it is concluded that Pamplefleur shows no evidence of mutagenic potential or bone marrow cell toxicity when administered orally in this in vivo test procedure.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The test material is not classified for genotoxicity based on the Ames study and an in vivo mouse micronucleus study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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