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Diss Factsheets
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EC number: 279-815-0 | CAS number: 81782-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In Vitro bacterial reverse mutation test (Ames).
The key study for this endpoint, Verspeek-Rip (2002), was performed to the standardised guidelines OECD 471and EU Method B.13/14 and in compliance with GLP. The study was performed and reported to a high standard. In accordance with the criteria for assessing data quality as described by Klimisch (1997), the study was assigned a reliability score of 1. The study was performed using both the direct plate and preincubation methods. Salmonella typhimurium strains TA98, TA 100, TA 102, TA 1535 and TA 1537 were exposed to varying concentrations of the test material, on 4-methyl-4-decen-5-ol, in the presence and absence of metabolic activation. Under the conditions of the study, the test material was non-mutagenic in the Salmonella typhimurium reverse mutation assay both in the presence and in the absence of metabolic activation. Under the conditions of the test, the test substance was found to be non-mutagenic in S. typhimurium strains TA100, TA98, TA1535 and TA1537 in both the presence and absence of metabolic activation.
Jagannath (1981) was provided as supporting information to the key in vitro genetic mutations study in bacteria data requirement. The study was performed in compliance with GLP following a similar protocol to the one set out in Ames et al (1975), the mutagenicity of the test material (4-methyl-4-decen-5-ol ) was determined in five strains of Salmonella typhimurium.TA 98, TA 100, TA 1535, TA 1537 and TA 1538 were exposed to varying concentrations of the test material in the presence and absence of the metabolic activation. Under the conditions of the test the test material gave a negative response both in the presence and in the absence of metabolic activation and is considered to be non-mutagenic in the bacterial strains of Salmonella typhimurium tested. The study was performed to a high standard, however, the raw data reporting the results was not available. It was therefore not possible to confirm the conclusions of the study based on the available data. Therefore in accordance with the principles for assessing data quality as described in Klimisch (1997), the study was assigned a reliability score of 2.
In Vitro mammalian cell gene mutation test
The test material has been assessed by read-across to structural, mechanistically similar substance using the OECD QSAR Toolbox to predict the potential of the target substance to induce gene mutations and structural chromosome aberrations in a mammalian cell line.
In Vitro mammalian chromosome aberration test
The test material has been assessed by read-across to structural, mechanistically similar substance using the OECD QSAR Toolbox to predict the potential of the target substance to induce structural aberrations in a cell line.
In Vivo mammalian erythrocyte micronucleus test
The test material has been assessed by read-across to structural, mechanistically similar substance using the OECD QSAR Toolbox to predict the potential of the target substance to induce structuraland numerical aberrations.
Justification for classification or non-classification
According to the EU Regulation EC 1272/2008 and Directive 67/548/EEC, the test material does not meet the criteria for classification for germ cell mutagenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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