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EC number: 277-918-5 | CAS number: 74543-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox version 3.4 and the QMRAF report has been attached.
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Version / remarks:
- No data available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Prediction was done using the OECD QSAR toolbox version 3.4.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: sodium hydrogen 8-aminonaphthalene-1,6-disulfonate
- Molecular formula: C10H8NNaO6S2
- Molecular weight: 325.2962 g/mol
- Smiles notation: c1cc2cc(cc(c2c(c1)S(=O)(=O)O)N)S(=O)(=O)[O-].[Na+]
- InChl: 1S/C10H9NO6S2.Na/c11-8-5-7(18(12,13)14)4-6-2-1-3-9(10(6)8)19(15,16)17;/h1-5H,11H2,(H,12,13,14)(H,15,16,17);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No data available
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- No data available
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- 20±1°C
- pH:
- 6.9-7.4
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Conductivity:
- No data available
- Nominal and measured concentrations:
- No data available
- Details on test conditions:
- No data available
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 194.354 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: Intoxication
- Remarks on result:
- other: Non toxic
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the intoxication of daphnia magna due to the exposure of sodium hydrogen 8-aminonaphthalene-1,6-disulfonate, the EC50 for 48hrs was 194.355 mg/l.
- Executive summary:
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for sodium hydrogen 8-aminonaphthalene-1,6-disulfonate (74543-22-9). The EC50 value was estimated to be 194.355 mg/l when sodium hydrogen 8-aminonaphthalene-1,6-disulfonate exposed to Daphnia magna for 48hrs.
Thus based on the EC50 value sodium hydrogen 8-aminonaphthalene-1,6-disulfonate was consider as nontoxic and can be consider to be not classified as per the CLP classification criteria.
Reference
The
prediction was based on dataset comprised from the following
descriptors: EC50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((((("a"
or "b" or "c" or "d" or "e" or "f" )
and "g" )
and "h" )
and ("i"
and (
not "j")
)
)
and ("k"
and (
not "l")
)
)
and ("m"
and (
not "n")
)
)
and ("o"
and (
not "p")
)
)
and ("q"
and (
not "r")
)
)
and ("s"
and "t" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Naphthalene sulfonic acids,
condensates by OECD HPV Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Anilines (Acute toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Non-covalent interaction AND
Non-covalent interaction >> DNA intercalation AND Non-covalent
interaction >> DNA intercalation >> Fused-Ring Primary Aromatic Amines
AND Radical AND Radical >> Radical mechanism via ROS formation
(indirect) AND Radical >> Radical mechanism via ROS formation (indirect)
>> Fused-Ring Primary Aromatic Amines AND SN1 AND SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation AND SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation >> Fused-Ring Primary
Aromatic Amines by DNA binding by OASIS v.1.4
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as AN2 AND AN2 >> Michael-type
addition to quinoid structures AND AN2 >> Michael-type addition to
quinoid structures >> Substituted Anilines by Protein binding by OASIS
v1.4
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Strong binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Acid moiety AND Anilines
(Unhindered) AND Salt by Aquatic toxicity classification by ECOSAR
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Class 5 (Not possible to
classify according to these rules) by Acute aquatic toxicity
classification by Verhaar (Modified) ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Reactive unspecified by Acute
aquatic toxicity MOA by OASIS ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Aniline AND Fused carbocyclic
aromatic AND Naphtalene AND Overlapping groups AND Sulfonic acid by
Organic Functional groups (nested)
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Benzamide by Organic Functional
groups (nested)
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Aniline AND Fused carbocyclic
aromatic AND Naphtalene AND Overlapping groups AND Sulfonic acid by
Organic Functional groups (nested)
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Ether by Organic Functional
groups (nested)
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Aniline AND Fused carbocyclic
aromatic AND Naphtalene AND Overlapping groups AND Sulfonic acid by
Organic Functional groups (nested)
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Aliphatic Amine, secondary by
Organic Functional groups (nested)
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Aniline AND Fused carbocyclic
aromatic AND Naphtalene AND Overlapping groups AND Sulfonic acid by
Organic Functional groups (nested)
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Thiazole/ Isothiazole by Organic
Functional groups (nested)
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Amine AND Anion AND Aromatic
compound AND Cation AND Primary amine AND Primary aromatic amine AND
Sulfonic acid AND Sulfonic acid derivative by Organic functional groups,
Norbert Haider (checkmol)
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as CO2 derivative (general) by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "s"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -7.08
Domain
logical expression index: "t"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= -0.333
Description of key information
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for sodium hydrogen 8-aminonaphthalene-1,6-disulfonate (74543-22-9). The EC50 value was estimated to be 194.355 mg/l when sodium hydrogen 8-aminonaphthalene-1,6-disulfonateexposed to Daphnia magna for 48hrs.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 194.355 mg/L
Additional information
Based on the various experimental data and prediction data for the target chemical, study have been reviewed to determine the toxic nature of sodium hydrogen 8-aminonaphthalene-1,6-disulfonate (74543-22-9) on the growth of aquatic invertebrates. The studies are as mentioned below
In the first weight of evidence predicted study for sodium hydrogen 8-aminonaphthalene-1,6-disulfonate (74543-22-9) from QSAR toolbox, 2017 Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for sodium hydrogen 8-aminonaphthalene-1,6-disulfonate (74543-22-9). The EC50 value was estimated to be 194.355 mg/l when sodium hydrogen 8-aminonaphthalene-1,6-disulfonateexposed to Daphnia magna for 48hrs.
Similarly in another expiremental report for RA chemical 4-amino-5-hydroxyna phthalene-1,7- disulphonic acid (130-23-4) from ABITEC lab report, 2016, Determination of the inhibition of the mobility of daphnids was carried out with the substance 4-amino-5-hydroxyna phthalene-1,7- disulphonic acid according to OECD Guideline 202. The test substance was tested at the concentrations 0, 0, 0, 5, 10, 25, 50, 100, 200 mg/l.. Effects on immobilisation were observed for 48 hours. The median effective concentration (EC50) for the test substance, 4-amino-5-hydroxyna phthalene-1,7- disulphonic acid in Daphnia magna was determined to be 500 mg/L for immobilisation effects. This value indicates that the substance is likely to be non-hazardous to aquatic invertebrates and cannot be classified as per the CLP criteria.
Similarly in the third weight of evidence study for the RA chemical (121-57-3) from chemosphere 1994, Toxicological profile of sulphanilic acid were study on the daphnia magna for 24 hrs. From the study the EC50 value for short term toxicity to aquatic invertebrates for sulphanilic acid in 24 hrs was determined to be 109.13 mg/l. Based on the result, sulphanilic acid (121-57-3) was considered as not toxic and not classified as per the CLP regulations.
Similarly in the fourth weight of evidence study for the RA chemical (121-57-3) from IUCLID dataset, The short term toxicity study of sulphanilic acid to aquatic invertebrates was performed on Daphnia magna. Test was performed by static system. After the 24 hrs of exposure with chemical, the EC50 and EC100 value for Daphnia magna for Sulphanilic Acid (121-57-3) was determined to be 109.13 and 250 mg/l. Based on the value the sulphanilic Acid was considered to be non-toxic to aquatic invertebrate and can be considered to be not classified as per CLP regulations.
Based on the data obtain from various sources for target and RA chemicals, it can be concluded that the substance sodium hydrogen 8-aminonaphthalene-1,6- disulfonate (74543-22-9) is considered to be not toxic to aquatic environment and cannot be classified as toxic as per the criteria mentioned in CLP regulation.
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