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EC number: 246-896-9 | CAS number: 25360-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key skin, eye, and respiratory irritation data are available for 1,1-dimethylheptanethiol.
Skin Irritation: Not irritating
Eye Irritation: Not irritating
Respiratory Irritation: Not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation
In a key dermal irritation study (Rees, 2012; Klimisch score = 1), three New Zealand White rabbits were dermally administered 0.5 mL of 1,1-dimethylheptanethiol. The test material was applied undiluted to the clipped dorso-lumbar region of each animal and covered with semi-occlusive wrap for a period of 4 hours. An additional site was similarly treated with the exception of test substance and acted as a control. All animals were subsequently observed for a period of four days.
Very-slight erythema and oedema were apparent at the test site of one animal one hour after bandage removal. The erythema persisted to the 24 hour examination but all test sites were normal 48 hours after bandage removal. The mean 24-, 48-, and 72-hour erythema and oedema scores were 0. No other signs of test-material related clinical toxicity were observed during the study.
Based on the lack of effects observed in this study, 1,1-dimethylheptanethiol is not considered to be irritating to the rabbit skin.
Eye Irritation
In a key ocular irritation study (Rees, 2012; Klimisch score = 1), three New Zealand White rabbits were administered a single ocular dose (0.1 mL) of tert-nonanethiol and observed for 72 hours after instillation. The test material was instilled into the right eye by pulling the lower eyelid away from the eye ball to form a cup into which the test substance was dropped. The eyelids were then gently held together for one second before releasing; the left eye remained untreated. The treated eyes were not irrigated or rinsed after instillation.
There was no sign of toxicity or ill health in any rabbit during the observation period. Slight discharge was apparent in the treated eye of each animal one hour after instillation and the animals were overtly normal from 24 hours after instillation. Instillation of the test material gave rise to no or practically no initial pain response.
Tert-nonanethiol did not produce any ocular irritation in this study.
Respiratory Tract Irritation
In a key respiratory irritation tract study (Pence, 1983; Klimisch score = 2), four male outbred SPF mice were exposed via head-only inhalation to 7.00 mg/L (1067.5 ppm) of 1,1-dimethylheptanethiol for two periods of 1 minute exposures separated by a 10 minute exposure to room air. Animals were then observed for 5 minutes or until the respiratory rate returned to pre-exposure rates.
The test material was applied as a vapour in a head only exposure chamber attached to a plethymograph. One of the four mice demonstrated changes in respiratory rates during the first minute (0 -25% decrease in respiratory rate) and two mice in the second minute (0 -25% decrease in respiratory rate) of exposure to 7.00 mg/L1,1-dimethylheptanethiol. Based on the results the authors concluded that the test material is not an irritant when 7.00 mg/L is inhaled by mice. Compound-induced corrosion was not reported.
Justification for classification or non-classification
1,1-dimethylheptanethiol does not meet the criteria for classification and labelling as a skin irritant as defined by EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008.
1,1-dimethylheptanethiol does not meet the criteria for classification and labelling as a respiratory irritant as defined by EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008.
1,1-dimethylheptanethiol does not meet the criteria for classification as an ocular irritant under EU Dangerous Substances Directive 67/548/EEC or CLP EU Regulation 1272/2008.
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