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EC number: 242-980-4 | CAS number: 19351-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity, female/male mice, oral gavage, doses: 0, 480, 595, 738, 915, 1135, 1407, 1745 and 2164 mg/kg bw; Japanese Report and translated summary are available.
LD50 703.59 mg/kg bw in female mice and 798.97 mg/kg bw in male mice;
Mortality was observed from 30 minutes after the administration until two days afterwards. For males, mortality occured in the 595 mg/kg and higher dose groups; at doses ≥ 1135 mg/kg all males died. For females, mortality occured in the 595 mg/kg and higher dose groups; at doses ≥ 915 mg/kg, all females died.
Acute dermal toxicity: no study available
Acute inhalation toxicity: no study available
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-20-01 to 1987-07-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: translation of core data from a japanese study report, Japanese report available as well
- Principles of method if other than guideline:
- - Principle of test: 2,2-dimethylthiazolidine (DMT) was administered forcibly to male and female mice and the acute toxicity was observed.
- Parameters analysed / observed: general condition, body weight, mortality - GLP compliance:
- not specified
- Remarks:
- within translation
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- mouse
- Sex:
- male/female
- Route of administration:
- other: oral (administered forcibly)
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg
- Doses:
- 0, 480, 595, 738, 915, 1135, 1407, 1745 and 2164 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not given
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,histopathology - Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 703.59 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 639.95 - < 772.74
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 798.97 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 723.12 - < 883.4
- Mortality:
- The deaths were observed from 30 minutes after the administration until two days afterwards.
In the case of the males, death was observed in the 595 mg/kg and higher administration groups; moreover in the 1135 mg/kg and higher administration groups, all the animals died.
In the case of the females, death was observed in the 595 mg/kg and higher administration groups; moreover in the 915 mg/kg and higher administration groups, all the animals died. - Clinical signs:
- In terms of the general condition, sleepiness, walking on tiptoe, gait ataxia, "Kussmaul" respiration, half-closed eyes, mydriasis, lacrimation, tremor, clonic convulsions, nosebleed, etc. were observed from immediately after the administration.
No changes were observed from four days after the administration onwards. - Body weight:
- 595 mg/kg and higher dose groups: suppression or a tendency to suppression was seen in the body weights at day 7 and day 14 and also in the body weight gain over the period of days 0-14
- Gross pathology:
- - Animals found dead: dark reddening of lungs, black spots on the liver, red/reddish spots on the gastric mucosa, reddening/reddish-blackening of the small intestine-
- Terminal necropsy: kidney discoloration (grayish brown) was observed in many males. - Other findings:
- - Histopathology:
- Animals found dead: congestion of pulmonary blood
- Terminal necropsy: hepatic scar formation
Both were only observed in a small number of cases. - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 of 2,2-dimethylthiazolidine was 703.59 mg/kg bw in female mice and 798.97 mg/kg bw in male mice.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 703.59 mg/kg bw
- Quality of whole database:
- The study is regarded sufficient for classification and labelling although only a translated summary was available. The original japanese study report provides additional information in tabular form.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on relevant and adequate data, the test substance has to be classified according to the CLP Regulation (EC) No 1272/2008 with respect to acute oral toxicity, Category 4 and labelled with H302: Harmful if swallowed.
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