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EC number: 231-869-6 | CAS number: 7773-01-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-02-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted to GLP and to a current guideline.Read-across from MnSO4 to MnCl2 is considered scientifically valid, as the anions are not expected to exhibit different ecotoxicity and in both cases the cation Mn2+ is common to both substances and both substances are very soluble in water.
- Justification for type of information:
- See the read-across report attached in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- other: read-across target
Reference
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted on read-across material
- Justification for type of information:
- See the read-across report attached in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 560 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- manganese sulphate
- IUPAC Name:
- manganese sulphate
- Details on test material:
- - Name of test material (as cited in study report): MnSO4 (actually manganese sulphate monohydrate based on description in the GLP water solubility report)
- Physical state:solid
- Lot/batch No.: 08729
- Storage condition of test material: roomtemperature in the dark
- Other: extremely pale pink powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- Not applicable i.e. not performed after 3hrs
Test conditions
- Hardness:
- 140 mg/L as CaCO3
- Test temperature:
- 21+/-1°C
- pH:
- 7.2-7.9
- Dissolved oxygen:
- Initial reading = 4.7-7.0 mg/L
Final reading = 1.5- 3.7 mg/L - Salinity:
- Not applicable as freshwater used.
- Nominal and measured concentrations:
- Nominal concentrations were 10, 32, 100, 320 and 1000 mg MnSO4/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 500mL conical flask
- Type : open
- Aeration: yes
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 3.8g/L in actual activated sewage sludge, of which 16 ml used in tests.
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Alvaston water supply
- Total organic carbon: 1.018 mg/L average
- Metals: Aluminium < 15.57 µg/L average, iron < 11.4µg/L, mercury < 0.012µg/L, nickel < 3.04µg/L, lead < 2.3 µg/L, sodium 25µg/L, manganese < 1.5µg/L, Selenium < 0.5µg/L
- Pesticides: no single species was > 0.1 µg/L
- Chlorine: 0.307 mg/L
- Alkalinity: 7.62 average
- Conductivity: 386.192 µS/cm at 20°C
OTHER TEST CONDITIONS
- Light intensity: normal lighting
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : 0 hrs and after 30 min, and 3 hrs: Observation of test preparation. 3 hr: oxygen consumption rate
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Test concentrations: 10, 32, 100, 320, 1000 mg MnSO4/L - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 560 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- - Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no precipitation
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels: Variation in respiration rates of controls 1 and 2 after 3 hours contact time was ± 3%. - Reported statistics and error estimates:
- Not reported
Any other information on results incl. tables
Table 1 Oxygen Consumption Rates and Percentage Inhibition Values after 3 Hours Contact Time
Nominal Concentration (mg/l) |
Initial O2 (mg O2/l) |
Measurement Period (minutes) |
Final O2Reading (mg O2/l) |
O2Consumption Rates (mg O2/l/min) |
% Inhibition |
|
Control |
R1 |
6.0 |
7 |
2.5 |
0.50 |
- |
|
R2 |
4.8 |
4 |
2.7 |
0.53 |
- |
Test item |
10 |
4.7 |
6 |
1.5 |
0.53 |
[3] |
|
32 |
4.8 |
5 |
2.0 |
0.56 |
[9] |
|
100 |
5.2 |
5 |
2.5 |
0.54 |
[5] |
|
320 |
5.3 |
6 |
2.2 |
0.52 |
[1] |
|
1000 |
7.0 |
10 |
3.7 |
0.33 |
36 |
3,5-dichlorophenol |
3.2 |
5.9 |
10 |
1.6 |
0.43 |
17 |
|
10 |
7.3 |
10 |
5.2 |
0.21 |
59 |
|
32 |
8.0 |
10 |
7.2 |
0.08 |
84 |
[Increase in respiration rate as compared to controls]
R1– R2= Replicates 1 to 2
Table 2 pH Values of the Test Preparations at the Start and End of the Exposure Period
Nominal Concentration (mg/l) |
pH |
||
0 Hours |
3 Hours |
||
Control |
R1 |
7.5 |
7.9 |
|
R2 |
7.7 |
7.9 |
Test item |
10 |
7.6 |
7.8 |
|
32 |
7.5 |
7.8 |
|
100 |
7.5 |
7.7 |
|
320 |
7.3 |
7.7 |
|
1000 |
7.2 |
7.9 |
3,5-dichlorophenol |
3.2 |
7.5 |
8.0 |
|
10 |
7.5 |
8.1 |
|
32 |
7.6 |
8.3 |
R1– R2= Replicates 1 to 2
Table 3 Observations on the Test Preparations Throughout the Test Period
Nominal Concentration (mg/l) |
Observations on Test Preparations |
|||
0 Hours |
30 Minutes Contact Ti |
3 Hours Contact Ti |
||
Control |
R1 |
Dark brown dispersion |
Dark brown dispersion |
Dark brown dispersion |
|
R2 |
Dark brown dispersion |
Dark brown dispersion |
Dark brown dispersion |
Test item |
10 |
Clear colourless solution[1] |
Dark brown dispersion, no undissolved test item visible |
Dark brown dispersion, no undissolved test item visible |
|
32 |
Clear colourless solution* |
Dark brown dispersion, no undissolved test item visible |
Dark brown dispersion, no undissolved test item visible |
|
100 |
Clear colourless solution* |
Dark brown dispersion, no undissolved test item visible |
Dark brown dispersion, no undissolved test item visible |
|
320 |
Clear colourless solution* |
Dark brown dispersion, no undissolved test item visible |
Dark brown dispersion, no undissolved test item visible |
|
1000 |
Clear colourless solution* |
Dark brown dispersion, no undissolved test item visible |
Dark brown dispersion, no undissolved test item visible |
3,5-dichlorophenol |
3.2 |
Dark brown dispersion, no undissolved reference item visible |
Dark brown dispersion, no undissolved reference item visible |
Dark brown dispersion, no undissolved reference item visible |
|
10 |
Dark brown dispersion, no undissolved reference item visible |
Dark brown dispersion, no undissolved reference item visible |
Dark brown dispersion, no undissolved reference item visible |
|
32 |
Dark brown dispersion, no undissolved reference item visible |
Dark brown dispersion, no undissolved reference item visible |
Dark brown dispersion, no undissolved reference item visible |
R1– R2= Replicates 1 to 2
[1]Observations made prior to the addition of synthetic sewage and activated sewage sludge.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- MnSO4 is not considered toxic to micro-organisms in the STP with an EC50 > 1000 mg/L and No Observable Effect Concentration (NOEC) = 560 mg/L. In terms of Mn2+ this equates to EC50 >325 mg Mn/L and NOEC = 182 mg Mn/L. In turn this equates to EC50 > 744.5 mg MnCl2/L and NOEC = 416.7 mg MnCl2/L.
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